Viscogliosi G, Di Bernardo M G, Ettorre E, Chiriac I M
Giovanni Viscogliosi; Viale del Policlinico 155, 00100, Rome, Italy.
J Nutr Health Aging. 2017;21(5):593-596. doi: 10.1007/s12603-016-0816-9.
Impairment of physical performance might identify older people at higher risk of dementia over time. The present study evaluated handgrip strength as independent predictor of cognitive decline.
Observational, prospective. Follow-up duration: 11.2 ± 0.8 months.
Geriatric outpatients center. 104 consecutive stroke- and dementia-free older adults (44% men, ages 80.2 ± 5.4 years).
The Clinical Dementia Rating scale and the Clock Drawing Test (CDT) were administered. Handgrip strength was assessed using a Jamar hand dynamometer. Brain magnetic resonance imaging studies at 1.5 T were performed. White matter damage was expressed as severity of white matter hyperintensities (WMHs). Longitudinal changes in cognitive function were expressed as 1-year decline in CDT performance.
A robust association was observed between baseline handgrip strength and 1-year cognitive decline after multiple adjustment. Of note, the strength of such association was only minimally attenuated after adjusting for deep WMHs extent (β coefficient for handgrip strength = 0.183, SE= 0.038, p= 0.007, R2= 0.58).
Handgrip strength predicted accelerated 1-year decline in cognitive function, assessed by CDT, in a sample of older adults. Future studies are needed to elucidate the causal mechanisms linking limitations in physical function with dementia risk.
身体机能受损可能会识别出随着时间推移患痴呆症风险更高的老年人。本研究评估握力作为认知衰退的独立预测因素。
观察性、前瞻性研究。随访时长：11.2±0.8个月。
老年门诊中心。104名连续的无中风和无痴呆症的老年人（44%为男性，年龄80.2±5.4岁）。
采用临床痴呆评定量表和画钟试验（CDT）。使用Jamar握力计评估握力。进行1.5T的脑磁共振成像研究。白质损伤用白质高信号（WMHs）的严重程度表示。认知功能的纵向变化用CDT表现的1年衰退来表示。
在多次调整后，观察到基线握力与1年认知衰退之间存在强烈关联。值得注意的是，在调整深部WMHs范围后，这种关联的强度仅略有减弱（握力的β系数=0.183，标准误=0.038，p=0.007，R2=0.58）。
在一组老年人样本中，握力预测了通过CDT评估的认知功能1年加速衰退。需要进一步的研究来阐明将身体功能限制与痴呆症风险联系起来的因果机制。
