Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
Age Ageing. 2012 Jul;41(4):506-12. doi: 10.1093/ageing/afs013. Epub 2012 Feb 27.
cognitive decline and muscle weakness are prevalent health conditions in elderly people. We hypothesised that cognitive decline precedes muscle weakness.
to analyse the temporal relationship between cognitive performance and handgrip strength in oldest old people.
prospective population-based 4-year follow-up study.
a total of 555 subjects, all aged 85 years at baseline, were included into the study.
handgrip strength measured at age 85 and 89 years. Neuropsychological test battery to assess global cognitive performance, attention, processing speed and memory at baseline and repeated at age 89 years. Associations between handgrip strength and cognitive performance were analysed by repeated linear regression analysis adjusted for common confounders.
at age 85 and 89 years, better cognitive performance was associated with higher handgrip strength (all, P<0.03), except for attention. There was no longitudinal association between baseline handgrip strength and cognitive decline (all, P>0.10), except for global cognitive performance (P=0.007). Better cognitive performance at age 85 years was associated with slower decline in handgrip strength (all, P<0.01) after adjustment for common confounders.
baseline cognitive performance was associated with decline in handgrip strength, whereas baseline handgrip strength was not associated with cognitive decline. Our results suggest that cognitive decline precedes the onset of muscle weakness in oldest old people.
认知能力下降和肌肉力量减弱是老年人常见的健康问题。我们假设认知能力下降先于肌肉力量减弱。
分析最年长老年人认知表现和握力之间的时间关系。
前瞻性人群基础 4 年随访研究。
共有 555 名受试者，所有受试者在基线时年龄均为 85 岁，纳入本研究。
在 85 岁和 89 岁时测量握力。神经心理测试套件用于评估基线和 89 岁时的整体认知表现、注意力、处理速度和记忆力。通过重复线性回归分析，调整常见混杂因素后，分析握力与认知表现之间的相关性。
在 85 岁和 89 岁时，更好的认知表现与更高的握力相关（均 P<0.03），除了注意力。基线握力与认知能力下降之间没有纵向关联（均 P>0.10），除了整体认知表现（P=0.007）。在调整常见混杂因素后，85 岁时更好的认知表现与握力下降速度较慢相关（均 P<0.01）。
基线认知表现与握力下降相关，而基线握力与认知能力下降无关。我们的结果表明，认知能力下降先于最年长老年人肌肉力量减弱的发生。
