Wang Jianquan, Lee Gee Young, Lu Qian, Peng Xianghong, Wu Jiangxiao, Wu Siyuan, Kairdolf Brad A, Nie Shuming, Wang Yiqing, Lane Lucas A
Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University , Nanjing, Jiangsu 210093, China.
Department of Biomedical Engineering, Emory University and Georgia Institute of Technology , Atlanta, Georgia 30322, United States.
Bioconjug Chem. 2017 May 17;28(5):1351-1355. doi: 10.1021/acs.bioconjchem.7b00138. Epub 2017 May 3.
Targeted and nontargeted biopolymeric nanoparticles with identical hydrodynamic sizes and surface charges were quantitatively examined in terms of the pharmacokinetic and biodistribution differences in detail. In adding cancer cell targeting folate molecules to the surface of the heparin nanocarriers, the amount of drug delivered to the tumor is doubled, and tumor growth inhibition is significantly enhanced. The folate-targeted heparin particles offered similar therapeutic potentials compared to their synthetic long-circulating analogues, thus presenting a viable alternative for drug-delivery vehicle construction using biological polymers, which are easier for the body to eliminate.
对具有相同流体动力学尺寸和表面电荷的靶向和非靶向生物聚合物纳米颗粒的药代动力学和生物分布差异进行了详细的定量研究。在肝素纳米载体表面添加癌细胞靶向叶酸分子后，输送到肿瘤的药物量增加了一倍，肿瘤生长抑制作用显著增强。与合成的长效循环类似物相比，叶酸靶向肝素颗粒具有相似的治疗潜力，因此为使用生物聚合物构建药物递送载体提供了一种可行的替代方案，生物聚合物更容易被身体清除。
