Wei Wenbo, Jia Guang, von Tengg-Kobligk Hendrik, Heverhagen Johannes T, Abdel-Rahman Mohamed, Wei Lai, Christoforidis John B, Davidorf Frederick, Knopp Michael V
From the *Wright Center of Innovation in Biomedical Imaging and Department of Radiology, The Ohio State University, Columbus, OH; †Department of Physics and Astronomy, Louisiana State University, Baton Rouge, LA; ‡Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, University of Bern, Bern, Switzerland; §Department of Ophthalmology and Visual Science, and ∥Center for Biostatistics, Department of Biomedical Informatics, The Ohio State University, Columbus, OH; and ¶Department of Ophthalmology and Vision Science, The University of Arizona Medical Center, Tucson, AZ.
J Comput Assist Tomogr. 2017 Sep/Oct;41(5):823-827. doi: 10.1097/RCT.0000000000000598.
This study explores the capability of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to differentiate tumor characteristics of metastatic and nonmetastatic choroidal melanoma as a potential tool for patient management.
A total of 13 patients (69 ± 9 years) with choroidal melanoma were imaged using DCE-MRI on a 3-T MRI system with a 16-channel head coil. The Tofts 2-compartment model was chosen for quantification, and parameters K (the transfer constant from the blood plasma to the extracellular space) and Kep (the transfer constant from the extracellular space to the blood plasma) were calculated and compared. Metastasis was excluded by subsequent clinical work-up or confirmed by histology after targeted biopsy.
Six patients were diagnosed with metastatic melanoma and 7 without. All orbital tumors were at least larger than 2 mm. A significant difference was identified in K between patients with (0.73 ± 0.18/min) and without (1.00 ± 0.21/min) metastatic melanoma (P = 0.03), whereas the difference was not significantly shown in Kep (2.58 ± 1.54/min of metastatic patients vs 2.98 ± 1.83/min of nonmetastatic patients, P = 0.67).
Dynamic contrast-enhanced magnetic resonance imaging has the potential to differentiate orbital melanomas with metastatic and nonmetastatic spread. Thus, DCE-MRI has the potential to be an in vivo imaging technique to predict early which patients are prone to metastatic disease.
本研究探讨动态对比增强磁共振成像（DCE-MRI）区分转移性和非转移性脉络膜黑色素瘤肿瘤特征的能力，作为一种潜在的患者管理工具。
共有13例（69±9岁）脉络膜黑色素瘤患者在配备16通道头部线圈的3-T MRI系统上进行DCE-MRI成像。选择Tofts双室模型进行定量分析，计算并比较参数K（从血浆到细胞外间隙的转移常数）和Kep（从细胞外间隙到血浆的转移常数）。通过后续临床检查排除转移，或在靶向活检后经组织学证实转移。
6例患者被诊断为转移性黑色素瘤，7例未发生转移。所有眼眶肿瘤至少大于2mm。转移性黑色素瘤患者（0.73±0.18/min）和非转移性黑色素瘤患者（1.00±0.21/min）之间的K值存在显著差异（P = 0.03），而Kep值差异无统计学意义（转移性患者为2.58±1.54/min，非转移性患者为2.98±1.83/min，P = 0.67）。
动态对比增强磁共振成像有潜力区分有转移和无转移扩散的眼眶黑色素瘤。因此，DCE-MRI有潜力成为一种体内成像技术，用于早期预测哪些患者易发生转移性疾病。
