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老年人在精神科和初级保健中接受抗抑郁药、苯二氮䓬类药物及其他镇静催眠药物治疗的全国趋势

National Trends in Antidepressant, Benzodiazepine, and Other Sedative-Hypnotic Treatment of Older Adults in Psychiatric and Primary Care.

作者信息

Maust Donovan T, Blow Frederic C, Wiechers Ilse R, Kales Helen C, Marcus Steven C

机构信息

Department of Psychiatry, University of Michigan, NCRC 016-222W, 2800 Plymouth Rd, Ann Arbor, MI 48109.

Department of Psychiatry and Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, and Center for Clinical Management Research, VA Ann Arbor Healthcare System, Michigan, USA.

出版信息

J Clin Psychiatry. 2017 Apr;78(4):e363-e371. doi: 10.4088/JCP.16m10713.

Abstract

OBJECTIVE

To describe how use of antidepressants, benzodiazepines, and other anxiolytic/sedative-hypnotics among older adults (age ≥ 65 years) has changed over time among visits to primary care providers and psychiatrists.

METHODS

Data were from the National Ambulatory Medical Care Survey (years 2003-2005 and 2010-2012), a nationally representative cross-section of outpatient physician visits. Analysis focused on visits to primary care providers (n = 14,282) and psychiatrists (n = 1,095) at which an antidepressant, benzodiazepine, or other anxiolytic/sedative-hypnotic was prescribed, which were stratified by demographic and clinical characteristic (including ICD-9-CM diagnosis) and compared across study intervals. Odds of medication use were calculated for each stratum, adjusting for demographic and clinical characteristics.

RESULTS

The visit rate by older adults to primary care providers where any of the medications were prescribed rose from 16.4% to 21.8% (adjusted odds ratio [AOR] = 1.43, P < .001) while remaining steady among psychiatrists (75.4% vs 68.5%; AOR = 0.69, P = .11). Primary care visits rose for antidepressants (9.9% to 12.3%; AOR = 1.28, P = .01) and other anxiolytic/sedative-hypnotics (3.4% to 4.7%; AOR = 1.39, P = .01), but the largest growth was among benzodiazepines (5.6% to 8.7%; AOR = 1.62, P < .001). Among patients in primary care, increases primarily occurred among men, non-Hispanic white patients, and those with pain diagnoses as well as those with no mental health or pain diagnoses.

CONCLUSIONS

From 2003 to 2012, use of the most common psychotropic medications among older adults seen in primary care increased, with concentration among patients with no mental health or pain diagnosis. As the population of older adults grows and receives mental health treatment in primary care, it is critical to examine the appropriateness of psychotropic use.

摘要

目的

描述65岁及以上老年人在就诊于初级保健提供者和精神科医生时,抗抑郁药、苯二氮䓬类药物及其他抗焦虑/镇静催眠药物的使用情况随时间发生了怎样的变化。

方法

数据来自国家门诊医疗调查(2003 - 2005年及2010 - 2012年),这是一项具有全国代表性的门诊医生就诊情况横断面调查。分析聚焦于就诊于初级保健提供者(n = 14282)和精神科医生(n = 1095)且开具了抗抑郁药、苯二氮䓬类药物或其他抗焦虑/镇静催眠药物的就诊情况,这些情况按人口统计学和临床特征(包括国际疾病分类第九版临床修订本[ICD - 9 - CM]诊断)进行分层,并在各研究时间段进行比较。计算每个分层使用药物的比值比,并对人口统计学和临床特征进行调整。

结果

在开具了任何一种此类药物的情况下,老年人就诊于初级保健提供者的比例从16.4%升至21.8%(调整后的比值比[AOR]=1.43,P < 0.001),而在精神科医生处就诊的比例保持稳定(75.4%对68.5%;AOR = 0.69,P = 0.11)。初级保健就诊中,抗抑郁药(9.9%至12.3%;AOR = 1.28,P = 0.01)和其他抗焦虑/镇静催眠药物(3.4%至4.7%;AOR = 1.39,P = 0.01)的就诊比例上升,但增长最大的是苯二氮䓬类药物(5.6%至8.7%;AOR = 1.62,P < 0.001)。在初级保健患者中,增长主要发生在男性、非西班牙裔白人患者、有疼痛诊断的患者以及无心理健康或疼痛诊断的患者中。

结论

从2003年到2012年,初级保健中所见老年人使用最常见精神药物的情况有所增加,且集中在无心理健康或疼痛诊断的患者中。随着老年人口增长且在初级保健中接受心理健康治疗,审查精神药物使用的适宜性至关重要。

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