Ghosh Soumitra, Bhuyan Dhrubajyoti
Department of Psychiatry, Assam Medical College and Hospital, Dibrugarh, Assam, India.
Clin Psychopharmacol Neurosci. 2017 May 31;15(2):187-189. doi: 10.9758/cpn.2017.15.2.187.
Baclofen is a gamma-aminobutyric acid type B receptor agonist used as an anti-craving agent for treatment of alcohol dependence. It has gained popularity in the recent times because it is well tolerated even in patients with hepatic impairments. Herein we are summarizing the latest literature about baclofen induced hypomania and are reporting a case of baclofen abuse because of its mood elevating property in a patient of alcohol dependence with comorbid major depressive disorder. Literature review and case study of a 36-year-old male with alcohol dependence with comorbid major depressive disorder was prescribed with tablet baclofen as an anti-craving agent along with antidepressant medicines. The patients who did not improve with conventional antidepressant therapy started feeling better in terms of his mood symptoms on taking tablet baclofen. Owing to the mood elevating property he started abusing baclofen. Despite its safety profile in hepatic impairment, one must be very cautious in prescribing baclofen because of its mood altering property which may account for its abuse potentiality.
巴氯芬是一种γ-氨基丁酸B型受体激动剂，用作治疗酒精依赖的抗渴求药物。近年来它颇受关注，因为即使是肝功能受损的患者也能很好地耐受。在此，我们总结了关于巴氯芬诱发轻躁狂的最新文献，并报告了一例酒精依赖合并重度抑郁症患者因巴氯芬具有情绪提升作用而滥用该药的病例。对一名36岁酒精依赖合并重度抑郁症男性患者进行文献回顾和病例研究，该患者被开具巴氯芬片作为抗渴求药物，同时服用抗抑郁药。那些常规抗抑郁治疗效果不佳的患者在服用巴氯芬片后情绪症状开始有所改善。由于其情绪提升作用，他开始滥用巴氯芬。尽管巴氯芬在肝功能损害方面具有安全性，但因其具有情绪改变作用，可能导致滥用可能性，所以在开具巴氯芬处方时必须非常谨慎。
