Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Curr Psychiatry Rep. 2019 Mar 9;21(4):23. doi: 10.1007/s11920-019-1009-0.
Phenibut (β-phenyl-γ-aminobutyric acid) is a psychoactive GABA analogue currently being marketed online as an anxiolytic and nootropic dietary supplement. Its use is growing in popularity, but its pharmacological activity is well beyond that of a conventional nutritional supplement, and similar to that of a prescription strength sedative. This review will focus on the potential adversities of phenibut use and will discuss what treatment options may be beneficial to afflicted patients.
Over the last several years, multiple case reports have highlighted phenibut's potential to produce the conditions of physical dependence, withdrawal, and addiction. In cases involving intoxication, patients have presented with a varying degree of mental status changes, from being minimally responsive to manifesting symptoms of an agitated delirium. Phenibut is a potent psychoactive substance with GABA agonist properties, which is emerging as a drug of misuse through growing internet sales. Its marketing as a "dietary supplement" is inaccurate and misleading, given its pharmacological profile and ability to induce the physiological changes associated with withdrawal and physical dependence.
苯并呋喃（β-苯基-γ-氨基丁酸）是一种具有精神活性的 GABA 类似物，目前在网上作为一种抗焦虑和益智的膳食补充剂销售。它的使用越来越受欢迎，但它的药理活性远远超出了传统的营养补充剂，类似于处方强度的镇静剂。这篇综述将集中讨论苯并呋喃使用的潜在危害，并讨论哪些治疗选择可能对受影响的患者有益。
在过去的几年中，多项病例报告强调了苯并呋喃产生身体依赖、戒断和成瘾的可能性。在涉及中毒的情况下，患者表现出不同程度的精神状态改变，从反应迟钝到明显的激越性谵妄症状。苯并呋喃是一种具有 GABA 激动剂特性的强效精神活性物质，通过日益增长的互联网销售，已成为一种被滥用的药物。将其作为“膳食补充剂”进行营销是不准确和误导性的，因为它的药理学特征和诱导与戒断和身体依赖相关的生理变化的能力。
