Bolu Abdullah, Akarsu Süleyman, Pan Erdal, Aydemir Emre, Oznur Taner
Aircrew's Health Research and Training Center, Eskişehir, Turkey.
Department of Psychiatry, Iskenderun Military Hospital, Hatay, Turkey.
Clin Psychopharmacol Neurosci. 2017 May 31;15(2):190-193. doi: 10.9758/cpn.2017.15.2.190.
Seizures are believed to be a dose-dependent side effect of clozapine. In this case report, we describe a patient who had tonic-clonic seizures after using a low dose clozapine who did not have any seizure risk. The 29-year-old male patient had been followed-up with a diagnosis of schizophrenia for about 5 years. When using clozapine 200 mg/day he had a tonic-clonic seizure with bilateral diffuse epileptic activity in electroencephalography (EEG). In the literature, there are a few case reports about low-dose clozapine-induced seizure. Seizures were observed in our case with a low dose of clozapine (200 mg/day) making this case remarkable. EEG monitoring at regular intervals and examination of plasma levels of clozapine could be useful in preventing the development of seizures.
癫痫发作被认为是氯氮平的剂量依赖性副作用。在本病例报告中，我们描述了一名使用低剂量氯氮平后出现强直阵挛性发作的患者，该患者并无任何癫痫发作风险。这位29岁的男性患者因精神分裂症接受随访约5年。当使用氯氮平200毫克/天时，他出现了强直阵挛性发作，脑电图（EEG）显示双侧弥漫性癫痫活动。在文献中，有几例关于低剂量氯氮平诱发癫痫发作的病例报告。我们的病例在低剂量氯氮平（200毫克/天）时出现了癫痫发作，使得该病例引人注目。定期进行脑电图监测以及检测氯氮平的血浆水平可能有助于预防癫痫发作的发生。
