Oświęcimska Joanna, Malczyk Żaneta, Szymlak Agnieszka, Mikołajczak Agata, Ziora Katarzyna, Zamlynski Jacek, Machura Edyta, Zajac Piotr, Koczy Bogdan, Kasperska-Zajac Alicja
1 Department of Paediatrics, SMDZ in Zabrze, Medical University of Silesia in Katowice, Zabrze, Poland.
2 Department of Gynaecology, Obstetrics and Oncological Gynaecology, SMDZ in Zabrze, Medical University of Silesia in Katowice, Bytom, Poland.
Clin Appl Thromb Hemost. 2017 Sep;23(6):562-566. doi: 10.1177/1076029617705727. Epub 2017 Apr 28.
The significance of platelet size indices has not been widely analyzed in anorexia nervosa (AN). It seems important to get more knowledge on the easily available indices of platelet function obtained by routine complete blood count analysis in patients with AN. We analyzed platelet count (PLT), platelet distribution width (PDW), and mean platelet volume using an automated blood cell counter in 25 females with AN and healthy age- and gender-matched nonatopic controls. Mean PLT was significantly lower in patients with AN than in the control group. Platelet distribution width values in patients with AN were significantly higher than those in the controls. Platelet distribution width values significantly correlated with the disease duration and rate of body weight loss in the anorectic patients. Anorexia nervosa in adolescents is associated with a decrease in PLT along with an increased PDW, which may be an indicator of dysregulated thrombopoiesis.
血小板大小指标在神经性厌食症（AN）中的意义尚未得到广泛分析。对于通过常规全血细胞计数分析获得的、易于获取的血小板功能指标，在AN患者中获取更多相关知识似乎很重要。我们使用自动血细胞计数器分析了25名患有AN的女性以及年龄和性别匹配的健康非特应性对照者的血小板计数（PLT）、血小板分布宽度（PDW）和平均血小板体积。AN患者的平均PLT显著低于对照组。AN患者的血小板分布宽度值显著高于对照组。在厌食症患者中，血小板分布宽度值与病程和体重减轻率显著相关。青少年神经性厌食症与PLT降低以及PDW升高有关，这可能是血小板生成调节异常的一个指标。
