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美国功能性神经障碍诊所人群中神经精神症状与性别、病程、工作残疾及运动亚型的关联

Neuropsychiatric Associations With Gender, Illness Duration, Work Disability, and Motor Subtype in a U.S. Functional Neurological Disorders Clinic Population.

作者信息

Matin Nassim, Young Sigrid S, Williams Benjamin, LaFrance W Curt, King Julie N, Caplan David, Chemali Zeina, Weilburg Jeffery B, Dickerson Bradford C, Perez David L

机构信息

From the Cognitive Behavioral Neurology Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (NM, SSY, BW, JNK, DC, DLP); the Neuropsychiatry and Behavioral Neurology Division, Rhode Island Hospital, Departments of Psychiatry and Neurology, Brown University, Alpert Medical School, Providence, R.I. (WCL); the Neuropsychiatry Unit, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston (ZC, JBW, DLP); and the Frontotemporal Disorders Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (BCD, DLP).

出版信息

J Neuropsychiatry Clin Neurosci. 2017 Fall;29(4):375-382. doi: 10.1176/appi.neuropsych.16110302. Epub 2017 Apr 28.

Abstract

The assessment of functional neurological disorders (FND) requires an interdisciplinary approach. The authors retrospectively reviewed charts for 100 outpatients with FND and used univariate and regression analyses to investigate neuropsychiatric associations with gender, illness duration, and work disability; secondary analyses evaluated for differences across motor FND subtypes. Men reported higher rates of cognitive complaints and functional weakness, whereas women endorsed increased past physical/sexual trauma. Number of self-reported medication allergies/sensitivities positively correlated with illness duration. Individuals with functional weakness compared with other motor FND subtypes exhibited lower rates of past psychiatric hospitalization and head trauma. This study supports the feasibility of integrating FND research.

摘要

功能性神经障碍(FND)的评估需要采用跨学科方法。作者回顾性地查阅了100例FND门诊患者的病历,并使用单变量和回归分析来研究神经精神因素与性别、病程和工作残疾之间的关联;二次分析评估了运动性FND各亚型之间的差异。男性报告的认知主诉和功能性无力发生率较高,而女性则表示过去遭受身体/性创伤的经历更多。自我报告的药物过敏/敏感数量与病程呈正相关。与其他运动性FND亚型相比,功能性无力患者过去的精神科住院率和头部外伤率较低。本研究支持整合FND研究的可行性。

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