Helbig A Katharina, Stöckl Doris, Heier Margit, Thorand Barbara, Schulz Holger, Peters Annette, Ladwig Karl-Heinz, Meisinger Christa
Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
Sleep Med. 2017 May;33:151-159. doi: 10.1016/j.sleep.2017.01.016. Epub 2017 Feb 20.
BACKGROUND/OBJECTIVE: Although the association of disturbed sleep with specific chronic conditions is well known, the relationship between sleep disturbances and multiple diseases is less clear. Therefore, the objectives of this study were to examine the independent relationships of various sleep disturbances with 1) multimorbidity (≥2 chronic conditions) and 2) commonly co-occurring pairs of chronic conditions.
Analyses were based on data from 4127 individuals aged ≥65 years participating in the population-based cross-sectional Cooperative Health Research in the Region of Augsburg (KORA) Age Study conducted from 2008 to 2009 in Germany. Sex-specific odds ratios (OR) and 95% confidence intervals (CI) were calculated from sequential logistic regression models.
Neither short nor long daily sleep duration was significantly associated with multimorbidity among men; a significant positive relationship was identified regarding short sleep duration among women (OR 2.16, 95% CI: 1.42-3.30). While insomnia and all unique symptoms of insomnia were connected to multimorbidity among women in the multivariable models, the relationship concerning trouble falling asleep no longer remained significant after adjustment for all covariables among men. Regarding commonly co-occurring pairs of conditions, the clearest associations were observed between insomnia and daytime tiredness with joint diseases/eye diseases in men and joint diseases/heart diseases in women.
There seems to be sex-specific particularities in the relationship between sleep disturbances and sleep duration with multimorbidity and commonly co-occurring pairs of chronic conditions in older adults from the general population.
背景/目的：虽然睡眠障碍与特定慢性疾病之间的关联已为人熟知，但睡眠障碍与多种疾病之间的关系尚不清楚。因此，本研究的目的是探讨各种睡眠障碍与1）多病共存（≥2种慢性疾病）以及2）常见的慢性疾病共病组合之间的独立关系。
分析基于2008年至2009年在德国奥格斯堡地区进行的基于人群的横断面合作健康研究（KORA）年龄研究中4127名年龄≥65岁个体的数据。从序贯逻辑回归模型中计算特定性别的优势比（OR）和95%置信区间（CI）。
男性的每日睡眠时间无论是短还是长，均与多病共存无显著关联；女性的短睡眠时间与多病共存呈显著正相关（OR 2.16，95%CI：1.42 - 3.30）。在多变量模型中，失眠及所有失眠的独特症状与女性的多病共存相关，但在男性中，对所有协变量进行调整后，入睡困难与多病共存之间的关系不再显著。关于常见的共病组合，在男性中，失眠和日间疲劳与关节疾病/眼部疾病之间的关联最为明显；在女性中，失眠和日间疲劳与关节疾病/心脏病之间的关联最为明显。
在一般人群中，老年人的睡眠障碍、睡眠时间与多病共存以及常见的慢性疾病共病组合之间的关系似乎存在性别特异性。
