Yamada M, Shintani S, Mitani K, Kametani H, Wada Y, Furukawa T, Tsukagoshi H, Ozaki K, Eishi Y, Hatakeyama S
Department of Neurology, Tokyo Medical and Dental University, Japan.
J Neurol. 1988 Jul;235(6):368-70. doi: 10.1007/BF00314236.
An autopsy case of a 56-year-old woman who had carcinoma of the corpus uteri and peripheral neuropathy with predominantly motor manifestations is described. The neurological abnormalities included subacute weakness of the limbs and loss of deep reflexes, which improved after the surgical removal of the uterine carcinoma. Neuropathologically, peripheral nerves mainly presented features of axonal degeneration with a mild loss of myelinated fibres. Anterior horns of the spinal cord showed central chromatolysis of the motor nerve cells and many spheroids without neuronal loss. Axonopathy of peripheral nerves was considered to be the main pathological process in this paraneoplastic syndrome.
本文描述了一例56岁患有子宫体癌并伴有以运动症状为主的周围神经病变的女性尸检病例。神经学异常包括四肢亚急性无力和深反射消失，子宫癌手术切除后症状有所改善。神经病理学检查显示，周围神经主要表现为轴突变性，有轻度髓鞘纤维丢失。脊髓前角运动神经细胞出现中央性染色质溶解，并有许多神经球，但无神经元丢失。周围神经轴索性病变被认为是该副肿瘤综合征的主要病理过程。
