Vasku Marketa, Papathemelis Thomas, Maass Nicolai, Meinhold-Heerlein Ivo, Bauerschlag Dirk
Department of Gynecology and Obstetrics, University Medical Center Aachen, Pauwelsstraße 30, 52074 Aachen, Germany.
Case Rep Obstet Gynecol. 2011;2011:968756. doi: 10.1155/2011/968756. Epub 2011 Jul 12.
Paraneoplastic syndromes (PNS) are a heterogeneous group of symptoms which are indirectly caused by primary or metastatic tumor. Paraneoplastic polyneuropathy (PNP) is mostly related to small cell lung cancer (5%), prostate, gastric, and breast cancer. Only sporadic cases have been reported to be associated with endometrial cancer. We present a case of a premenopausal woman with severe vasculitic, asymmetric sensorimotor polyneuropathy that developed in conjunction with an endometrial carcinoma responding to surgical therapy of primary tumor combined to steroid therapy. Neurological symptoms such as asymmetrical sensorimotor deficits and painful paresthesias are suspicious when they occur in otherwise healthy women with no medical history. The phenomenon of a paraneoplastic syndrome can point to an underlying malignancy and can be used as marker of progression or regression of the tumor. Due to the rarity of PNP, there is no standard treatment. Recommended therapy is stage-adjusted treatment of the primary tumor.
副肿瘤综合征（PNS）是由原发性或转移性肿瘤间接引起的一组异质性症状。副肿瘤性多发性神经病（PNP）大多与小细胞肺癌（5%）、前列腺癌、胃癌和乳腺癌有关。仅有散发病例报道与子宫内膜癌相关。我们报告一例绝经前女性，患有严重的血管炎性、不对称性感觉运动性多发性神经病，该疾病与子宫内膜癌同时发生，对原发性肿瘤的手术治疗联合类固醇治疗有反应。当无病史的健康女性出现不对称性感觉运动功能缺损和疼痛性感觉异常等神经症状时应引起怀疑。副肿瘤综合征现象可能提示潜在的恶性肿瘤，可作为肿瘤进展或消退的标志物。由于PNP罕见，尚无标准治疗方法。推荐的治疗是对原发性肿瘤进行分期调整治疗。
