Ahmad Mariam S, Frank Garett S, Hink Eric M, Palestine Alan G, Gregory Darren G, McCourt Emily A
Department of Ophthalmology, University of Colorado School of Medicine, Aurora, Colorado.
Department of Ophthalmology, University of Colorado School of Medicine, Aurora, Colorado.
J AAPOS. 2017 Jun;21(3):215-218. doi: 10.1016/j.jaapos.2017.04.002. Epub 2017 Apr 24.
To investigate the indications for and results of amniotic membrane transplantation (AMT) for the treatment of ocular disease in pediatric patients at a single institution.
The medical records of patients <18 years of age who underwent AMT for ocular disease between January 1, 2003, and September 1, 2015, were reviewed retrospectively. Patients were determined to have reached a clinical endpoint if there was resolution of the ocular condition being treated after AMT placement, no additional surgery required for treatment of the ocular condition, and no active disease at most recent follow-up.
A total of 48 records were reviewed. Of these, 32 patients (67%) received AMT for treatment of ocular disease related to Stevens Johnson syndrome (SJS), 29 (94%) of whom reached the clinical endpoint. The remaining 16 patients (33%) underwent AMT for indications other than SJS, including difficult-to-treat corneal epithelial defects and ulcers, conjunctival reconstruction, and scarring after strabismus surgery. Of these, 80% reached the clinical endpoint. There were no adverse effects related to AMT in either group.
In our series, AMT was used successfully and without complications.
在单一机构中研究羊膜移植（AMT）治疗儿科患者眼部疾病的适应证及疗效。
回顾性分析2003年1月1日至2015年9月1日期间18岁以下因眼部疾病接受AMT治疗的患者的病历。如果在放置AMT后所治疗的眼部疾病得到缓解，治疗该眼部疾病无需额外手术，且在最近一次随访时无活动性疾病，则判定患者达到临床终点。
共回顾了48份病历。其中，32例患者（67%）接受AMT治疗与史蒂文斯-约翰逊综合征（SJS）相关的眼部疾病，其中29例（94%）达到临床终点。其余16例患者（33%）因SJS以外的适应证接受AMT，包括难治性角膜上皮缺损和溃疡、结膜重建以及斜视手术后瘢痕形成。其中，80%达到临床终点。两组均未出现与AMT相关的不良反应。
在我们的系列研究中，AMT应用成功且无并发症。
