马拉加沙宁的全合成：一种具有不寻常立体化学结构的氯喹增强型吲哚生物碱。
Total synthesis of malagashanine: a chloroquine potentiating indole alkaloid with unusual stereochemistry.
作者信息
Kong A, Mancheno D E, Boudet N, Delgado R, Andreansky E S, Blakey S B
机构信息
Department of Chemistry , Emory University , 1515 Dickey Drive , Atlanta , GA 30322 , USA . Email:
出版信息
Chem Sci. 2017 Jan 1;8(1):697-700. doi: 10.1039/c6sc03578g. Epub 2016 Sep 19.
Abstract
The first total synthesis of malagashanine, a chloroquine potentiating indole alkaloid, is presented. A highly stereoselective cascade annulation reaction was developed to generate the tetracyclic core of the Malagasy alkaloids. This chemistry is likely to be broadly applicable to the synthesis of other members of this stereochemically unique family of natural products.
摘要
首次完成了对具有增强氯喹活性的吲哚生物碱马拉加沙宁的全合成。开发了一种高度立体选择性的串联环化反应来生成马达加斯加生物碱的四环核心。这种化学方法可能广泛适用于合成这一具有独特立体化学结构的天然产物家族的其他成员。
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