Zhang Xia, Chen Wei-Wei, Huang Wen-Juan
Department of Neurology, Xuzhou Central Hospital, Xuzhou, Jiangsu 221009, P.R. China.
Biomed Rep. 2017 Mar;6(3):267-271. doi: 10.3892/br.2017.851. Epub 2017 Jan 27.
Neuropathy is associated with side effects of frontline chemotherapeutics, which is a prominent therapy utilized in prevalent cancers. Peripheral neuropathy negatively impacts quality of life in cancer patients and survivors. It also affects the dose plan of the treatment, thereby limiting the efficacy of the treatment. We searched the electronic database PubMed for pre-clinically and clinically controlled trials reporting neuropathy of adverse effects, a result of chemotherapy in cancer patients. It was observed clearly that many reports provide clinical evidence to rapidly growing neuropathy cases of cancer patients. Furthermore, the reports clearly showed enhanced cold pain, sensorimotor deficits, sensory innervation of the skin and sensorimotor deficits in the patients with cancer who underwent treatment mainly with the chemotherapeutic approach. The present review highlighted the current view of peripheral neuropathy during chemotherapeutic approaches.
神经病变与一线化疗药物的副作用相关，一线化疗是常见癌症中使用的一种主要治疗方法。周围神经病变会对癌症患者及幸存者的生活质量产生负面影响。它还会影响治疗的剂量计划，从而限制治疗效果。我们在电子数据库PubMed中搜索了关于癌症患者化疗不良反应所致神经病变的临床前和临床对照试验。很明显可以观察到，许多报告为癌症患者迅速增加的神经病变病例提供了临床证据。此外，这些报告清楚地表明，主要接受化疗的癌症患者出现冷痛加剧、感觉运动功能障碍、皮肤感觉神经支配异常以及感觉运动功能障碍。本综述强调了化疗过程中周围神经病变的当前观点。
