Seth Nikita H, Raghuveer Raghumahanti, Qureshi Moh'd Irshad
Neurophysiotherapy, Ravi Nair Physiotherapy College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Cureus. 2024 Jun 19;16(6):e62732. doi: 10.7759/cureus.62732. eCollection 2024 Jun.
Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse reaction to many first- and second-line chemotherapy medications that can be debilitating, severe, and often dose-limiting. Treatment options for CIPN are limited. We report a case of a 52-year-old female patient with Stage II ovarian cancer who was hospitalised in the chemotherapy ward for a second round of chemotherapy. We describe the effectiveness of closed kinetic chain (CKC) exercises for the management of CIPN symptoms. The patient was advised to take neurophysiotherapy. The patient complained of pain, tingling in both feet, weakness in the lower limbs, and trouble keeping her balance while walking. Thus, three days after the start of the chemotherapy drugs, physical therapy rehabilitation was started. The patient stated total pain reduction and a noticeable improvement in tingling and numbness in both lower extremities following four weeks of physical therapy. Even though CIPN usually disappears gradually over time, it can persist for an extended period. It seems doubtful that this was a spontaneous resolve, given the regularity of her symptoms before starting physiotherapy sessions and their quick recovery with treatment. Further investigation is required to comprehend the role that physiotherapy and non-pharmacologic interventions play in ameliorating CIPN symptoms and to ascertain if improvements in CIPN symptoms are associated with an increase in blood flow directly or indirectly.
化疗引起的周围神经病变（CIPN）是许多一线和二线化疗药物常见的不良反应，可能会使人虚弱、严重，且常常限制剂量。CIPN的治疗选择有限。我们报告了一例52岁的II期卵巢癌女性患者，她因第二轮化疗入住化疗病房。我们描述了闭合动力链（CKC）运动对CIPN症状的管理效果。建议患者接受神经物理治疗。患者抱怨双脚疼痛、刺痛，下肢无力，行走时难以保持平衡。因此，在开始使用化疗药物三天后，开始进行物理治疗康复。患者表示，经过四周的物理治疗，疼痛完全减轻，双下肢的刺痛和麻木感明显改善。尽管CIPN通常会随着时间逐渐消失，但也可能会持续很长一段时间。考虑到她在开始物理治疗前症状的规律性以及治疗后症状迅速恢复，很难相信这是自发缓解。需要进一步研究以了解物理治疗和非药物干预在改善CIPN症状中所起的作用，并确定CIPN症状的改善是否与直接或间接的血流增加有关。
