Weinberg Anna, Shankman Stewart A
McGill University.
University of Illinois at Chicago.
Clin Psychol Sci. 2017 Jan;5(1):14-25. doi: 10.1177/2167702616633158. Epub 2016 May 20.
Blunted reward response appears to be a trait-like marker of vulnerability for Major Depressive Disorder (MDD). As such, it should be present in remitted individuals; however, depression is a heterogeneous syndrome. Reward-related impairments may be more pronounced in individuals with melancholic depression. The present study examined neural responses to rewards in remitted melancholic depression (rMD; N = 29), remitted non-melancholic depression (rNMD; N = 56), and healthy controls (HC; N = 81). Event-related potentials to monetary gain and loss were recorded during a simple gambling paradigm. rMD was characterized by a blunted response to rewards relative to both the HC and the rNMD groups, who did not differ from one another. Moreover, the rMD and rNMD groups did not differ in course or severity of their past illnesses, or current depressive symptoms or functioning. Results suggest that blunted response to rewards may be a viable vulnerability marker for melancholic depression.
奖赏反应迟钝似乎是重度抑郁症（MDD）易感性的一种特质样标志物。因此，它应该在病情缓解的个体中存在；然而，抑郁症是一种异质性综合征。与奖赏相关的损害在忧郁症性抑郁症患者中可能更为明显。本研究考察了病情缓解的忧郁症性抑郁症患者（rMD；N = 29）、病情缓解的非忧郁症性抑郁症患者（rNMD；N = 56）和健康对照者（HC；N = 81）对奖赏的神经反应。在一个简单的赌博范式中记录了与金钱得失相关的事件相关电位。相对于HC组和rNMD组，rMD组的特点是对奖赏反应迟钝，而HC组和rNMD组之间没有差异。此外，rMD组和rNMD组在既往疾病的病程或严重程度、当前抑郁症状或功能方面没有差异。结果表明，对奖赏反应迟钝可能是忧郁症性抑郁症一个可行的易感性标志物。
