Lee Hong J, Lee Dong S, Kwon Hyun B, Kim Do Y, Park Kwang S
Kwang Suk Park, Department of Biomedical Engineering, 717, Basic Science Building, Seoul National University College of Medicine, 103, Daehak-ro, Jongno-gu, Seoul, Republic of Korea, E-mail:
Methods Inf Med. 2017 Aug 11;56(4):319-327. doi: 10.3414/ME16-01-0067. Epub 2017 Apr 28.
The aim of this study is to develop an optimal electrode system in the form of a small and wearable single-patch ECG monitoring device that allows for the faithful reconstruction of the standard 12-lead ECG.
The optimized universal electrode positions on the chest and the personalized transformation matrix were determined using linear regression as well as artificial neural networks (ANNs). A total of 24 combinations of 4 neighboring electrodes on 35 channels were evaluated on 19 subjects. Moreover, we analyzed combinations of three electrodes within the four-electrode combination with the best performance.
The mean correlation coefficients were all higher than 0.95 in the case of the ANN method for the combinations of four neighboring electrodes. The reconstructions obtained using the three and four sensing electrodes showed no significant differences. The reconstructed 12-lead ECG obtained using the ANN method is better than that using the MLR method. Therefore, three sensing electrodes and one ground electrode (forming a square) placed below the clavicle on the left were determined to be suitable for ensuring good reconstruction performance.
Since the interelectrode distance was determined to be 5 cm, the suggested approach can be implemented in a single-patch device, which should allow for the continuous monitoring of the standard 12-lead ECG without requiring limb contact, both in daily life and in clinical practice.
本研究的目的是开发一种小型可穿戴单贴片心电图监测设备形式的最佳电极系统，该系统能够如实重建标准12导联心电图。
使用线性回归以及人工神经网络（ANN）确定胸部优化的通用电极位置和个性化变换矩阵。在19名受试者身上评估了35个通道上4个相邻电极的总共24种组合。此外，我们分析了具有最佳性能的四电极组合中的三电极组合。
对于四个相邻电极的组合，ANN方法的平均相关系数均高于0.9�。使用三个和四个传感电极获得的重建结果没有显著差异。使用ANN方法获得的重建12导联心电图优于使用多元线性回归（MLR）方法获得的结果。因此，确定在左锁骨下方放置三个传感电极和一个接地电极（形成一个正方形）适合确保良好的重建性能。
由于电极间距离确定为5厘米，建议的方法可以在单贴片设备中实现，这应该允许在日常生活和临床实践中连续监测标准12导联心电图，而无需肢体接触。
