Reincke M, Allolio B, Kaulen D, Jaursch-Hancke C, Winkelmann W
II. Medizinische Universitätsklinik, Köln-Merheim.
Klin Wochenschr. 1988 Aug 1;66(15):686-9. doi: 10.1007/BF01726927.
We investigated the effect of sodium valproate on plasma ACTH and serum cortisol concentrations in different pathological states of ACTH hypersecretion. Five patients with pituitary dependent Cushing's syndrome, two patients with Nelson's syndrome and five patients with Addison's disease were studied. Neither a single dose nor long term administration of sodium valproate resulted in a significant decrease of plasma ACTH levels in patients with Cushing's disease and Nelson's syndrome. Furthermore, the response of ACTH and cortisol to stimulation with lysine-vasopressin was unaffected during acute and chronic treatment. Patients with Addison's disease showed a slight attenuation of the ACTH response to lysine-vasopressin as compared to placebo but the difference was not statistically significant.
sodium valproate does not appear to be effective in controlling ACTH hypersecretion in pituitary dependent Cushing's syndrome.
我们研究了丙戊酸钠对促肾上腺皮质激素（ACTH）分泌过多的不同病理状态下血浆ACTH和血清皮质醇浓度的影响。研究了5例垂体依赖性库欣综合征患者、2例纳尔逊综合征患者和5例艾迪生病患者。无论是单次给药还是长期给予丙戊酸钠，均未导致库欣病和纳尔逊综合征患者血浆ACTH水平显著降低。此外，在急性和慢性治疗期间，ACTH和皮质醇对赖氨酸加压素刺激的反应未受影响。与安慰剂相比，艾迪生病患者对赖氨酸加压素的ACTH反应略有减弱，但差异无统计学意义。
丙戊酸钠似乎对控制垂体依赖性库欣综合征中的ACTH分泌过多无效。
