Pospos Sarah, Xi Min, Chen Guanjie, Zhang Ruiguo, Tan Qingrong, Baskys Andrius
a Memory Disorders Clinic and Riverside Psychiatric Medical Group , Riverside , California , USA.
b Xijing Hospital, Fourth Military Medical University (FMMU) , Xi'an , China.
Clin Gerontol. 2018 Jan-Feb;41(1):94-100. doi: 10.1080/07317115.2016.1272518. Epub 2017 Jan 18.
A 56-year old Chinese female was referred to an academic medical center with atypical, treatment-resistant depression that continued for approximately 3 years after her sister's death. Comprehensive evaluation including neurocognitive testing, EEG, spinal tap, HIV testing and brain MRI revealed behavioral variant of fronto-temporal dementia (bvFTD) with significant frontal and temporal lobe atrophy.This patient's unusual clinical presentation emphasizes the overlap between depression and bvFTD, and underlines the importance of prompt, accurate diagnosis to minimize often-ineffective pharmacological interventions and caregiver burnout.
一名56岁的中国女性被转诊至一家学术医疗中心，她患有非典型的、难治性抑郁症，在其妹妹去世后持续了约3年。综合评估包括神经认知测试、脑电图、腰椎穿刺、艾滋病毒检测和脑部核磁共振成像，结果显示为额颞叶痴呆的行为变异型（bvFTD），伴有明显的额叶和颞叶萎缩。该患者不同寻常的临床表现凸显了抑郁症与bvFTD之间的重叠，并强调了及时、准确诊断的重要性，以尽量减少往往无效的药物干预和照顾者的倦怠。
