Kudabayeva K, Batyrova G, Bazargaliyev Y, Agzamova R, Nuftieva A
West Kazakhstan Marat Ospanov State Medical University, Aktobe, the Republic of Kazakhstan.
Georgian Med News. 2017 Feb(263):64-71.
Aim of research - analysis of content of microelements in hair of children with thyromegaly living in the West Kazakhstan region. 159 school children of 6-12 years constantly living in this region were studied. Thyroid volume was measured by ultrasonography using an ultrasound scanner and evaluated according to body surface area and the gender in accordance with the WHO recommendations (2007). Microelements were measured by inductively coupled plasma mass spectrometry on NexION 300D (PerkinElmer Inc., USA). Excess value of the content of boron at 32.29% and silicon at 21.44% was found in children with goiter compared with those from control group. There was a reduction of cadmium at 37.38%, manganese - 26.48%, lead - 47%, vanadium - 15.5% compared with children with the normal volume of the thyroid gland. Correlation analysis showed a positive association of thyroid volume and hair trace elements Cu (r=0.423; p=0.001) and Si (r=0.202; p=0.01) and between I in hair and Hg (r=0.2978; p=0.001). The results of the multiple regression analysis revealed that the amount of thyroid is positively related to the concentration of copper and silicon in hair, and in less degree negatively with vanadium. The effect of these elements is 23%. Also found a positive dependence of iodine in the hair from indicators of mercury and negative from beryllium. Children with goiter show increased content of boron and silicon in hair and the decreased level of cadmium, manganese, lead, vanadium. The content of iodine in hair of children depends on the indicators of mercury and beryllium.
研究目的——分析哈萨克斯坦西部地区患有甲状腺肿大的儿童头发中的微量元素含量。对159名年龄在6至12岁、长期居住在该地区的在校儿童进行了研究。使用超声扫描仪通过超声检查测量甲状腺体积，并根据世界卫生组织（2007年）的建议，按照体表面积和性别进行评估。通过NexION 300D（美国珀金埃尔默公司）上的电感耦合等离子体质谱法测量微量元素。与对照组儿童相比，甲状腺肿儿童头发中的硼含量超标32.29%，硅含量超标21.44%。与甲状腺体积正常的儿童相比，镉含量降低了37.38%，锰含量降低了26.48%，铅含量降低了47%，钒含量降低了15.5%。相关性分析显示，甲状腺体积与头发中的微量元素铜（r = 0.423；p = 0.001）和硅（r = 0.202；p = 0.01）以及头发中的碘与汞（r = 0.2978；p = 0.001）之间呈正相关。多元回归分析结果显示，甲状腺的大小与头发中铜和硅的浓度呈正相关，与钒呈较弱的负相关。这些元素的影响为23%。还发现头发中的碘与汞指标呈正相关，与铍指标呈负相关。甲状腺肿儿童头发中的硼和硅含量增加，而镉、锰、铅、钒含量降低。儿童头发中的碘含量取决于汞和铍的指标。
