Kudabayeva Khatima I, Koshmaganbetova Gulbakit K, Mickuviene Narseta, Skalnaya Margarita G, Tinkov Alexey A, Skalny Anatoly V
West Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan.
Lithuanian University of Health Sciences, Kaunas, Lithuania.
Biol Trace Elem Res. 2016 Dec;174(2):261-266. doi: 10.1007/s12011-016-0711-6. Epub 2016 Apr 22.
The objective of the study was analysis of hair trace elements content in children with goiter living in Aktubinsk region. Children with goiter and age- and sex-adjusted controls were involved in the current study. Hair trace elements content was assessed using inductively coupled plasma mass spectrometry. Thyroid volume was measured using an ultrasound scanner and compared to the previously calculated normal values. The obtained data indicate that children with goiter were characterized by 20 and 15 % lower values of hair Cr and Zn, and 66, 42, 16, and 42 % higher hair levels of I, Mn, Si, and V as compared to the control values, respectively. Moreover, children with goiter were characterized by a twofold higher hair B levels than the control ones. Correlation analysis demonstrated a significant direct association only between thyroid volume and hair B (r = 0.482; p = 0.004), I (r = 0.393; p = 0.021), Mn (r = 0.364; p = 0.034), and Si (r = 0.446; p = 0.008) levels. It is also notable that hair I content was interrelated only with Si (r = 0.346; p = 0.045). No significant correlation was detected between I and B (r = 0.250; p = 0.155) and Mn (r = 0.076; p = 0.669) in hair of children. It is hypothesized that an increase in thyroid volume in children is associated with a complex interplay of iodine with other trace elements rather than with altered iodine status itself.
该研究的目的是分析生活在阿特劳地区的甲状腺肿大儿童头发中的微量元素含量。患有甲状腺肿大的儿童以及年龄和性别匹配的对照组参与了本研究。使用电感耦合等离子体质谱法评估头发中的微量元素含量。使用超声扫描仪测量甲状腺体积，并与先前计算的正常值进行比较。获得的数据表明，与对照组相比，甲状腺肿大儿童头发中的铬和锌含量分别低20%和15%，而碘、锰、硅和钒的含量分别高66%、42%、16%和42%。此外，甲状腺肿大儿童头发中的硼含量是对照组的两倍。相关性分析表明，仅甲状腺体积与头发中的硼（r = 0.482；p = 0.004）、碘（r = 0.393；p = 0.021）、锰（r = 0.364；p = 0.034）和硅（r = 0.446；p = 0.008）水平之间存在显著的直接关联。还值得注意的是，头发中的碘含量仅与硅相关（r = 0.346；p = 0.045）。在儿童头发中，未检测到碘与硼（r = 0.250；p = 0.155）和锰（r = 0.076；p = 0.669）之间存在显著相关性。据推测，儿童甲状腺体积的增加与碘与其他微量元素的复杂相互作用有关，而不是与碘状态的改变本身有关。
