Cicenas Jonas, Kvederaviciute Kotryna, Meskinyte Ingrida, Meskinyte-Kausiliene Edita, Skeberdyte Aiste, Cicenas Jonas
Vetsuisse Faculty, Institute of Animal Pathology, University of Bern, Länggassstrasse 122, 3012 Bern, Switzerland.
MAP Kinase Resource, Bioinformatics, Melchiorstrasse 9, 3027 Bern, Switzerland.
Cancers (Basel). 2017 Apr 28;9(5):42. doi: 10.3390/cancers9050042.
Pancreatic cancer is a disease that has a very high fatality rate and one of the highest mortality ratios among all major cancers, remaining the fourth leading cause of cancer-related deaths in developed countries. The major treatment of pancreatic cancer is surgery; however, only 15-20% of patients are candidates for it at the diagnosis of disease. On the other hand, survival in patients, who undergo surgery, is less than 30%. In most cancers, genome stability is disturbed and pancreatic cancer is not the exception. Approximately 97% of pancreatic cancers have gene derangements, defined by point mutations, amplifications, deletions, translocations, and inversions. This review describes the most frequent genetic alterations found in pancreatic cancer.
胰腺癌是一种死亡率极高的疾病，在所有主要癌症中死亡率位居前列，在发达国家仍是癌症相关死亡的第四大主要原因。胰腺癌的主要治疗方法是手术；然而，在疾病诊断时，只有15%至20%的患者适合手术。另一方面，接受手术的患者生存率不到30%。在大多数癌症中，基因组稳定性都会受到干扰，胰腺癌也不例外。大约97%的胰腺癌存在基因紊乱，表现为点突变、扩增、缺失、易位和倒位。本综述描述了胰腺癌中最常见的基因改变。
