Rawson J A, Wertheimer S, Rees S
Department of Physiology, Monash University, Clayton, Vic., Australia.
Neurosci Lett. 1988 Aug 15;91(1):14-8. doi: 10.1016/0304-3940(88)90241-8.
Harmaline has been used to produce long-term activation of the climbing fibre projection to the cerebellar cortex and the effects on parallel fibre transmission to Purkinje cells were studied electrophysiologically. The climbing fibre activation produced a profound depression in parallel fibre transmission which could be sustained for a period of more than two days. It was found that ongoing climbing fibre activity was necessary to maintain the depression at the synaptic junctions because transmission returned to normal within a matter of minutes if the climbing fibre input to the Purkinje cell was removed. This finding suggests that climbing fibre impulses do not induce permanent modifications in the efficacy of parallel fibre synapses.
哈尔满碱已被用于长期激活投射至小脑皮质的攀缘纤维，并且通过电生理学方法研究了其对平行纤维向浦肯野细胞传递的影响。攀缘纤维激活导致平行纤维传递出现深度抑制，这种抑制可持续两天以上。研究发现，持续的攀缘纤维活动对于维持突触连接处的抑制是必要的，因为如果去除浦肯野细胞的攀缘纤维输入，传递在几分钟内就会恢复正常。这一发现表明，攀缘纤维冲动不会诱导平行纤维突触效能的永久性改变。
