Ekerot C F, Kano M
Brain Res. 1985 Sep 9;342(2):357-60. doi: 10.1016/0006-8993(85)91136-9.
The results from several investigations suggest that climbing fibres heterosynaptically depress parallel fibre responses in Purkinje cells. In the present investigation the mechanism behind the depression has been studied by extracellular recording of responses in single Purkinje cells, evoked by electrical stimulation of parallel fibres and climbing fibres. The results show that a short time of conjunctive stimulation of climbing fibres and parallel fibres results in a long-lasting depression of the parallel fibre responses and that this depression can be prevented if the Purkinje cells are inhibited during the conjunctive stimulation. Since inhibition has been shown to shorten or abolish the long-lasting plateau potentials which are evoked by climbing fibre impulses this finding supports the assumption that the climbing fibre evoked plateau potentials mediate the heterosynaptic depression of parallel fibre responses.
多项研究结果表明，攀缘纤维以异突触方式抑制浦肯野细胞中的平行纤维反应。在本研究中，通过细胞外记录单个浦肯野细胞对平行纤维和攀缘纤维电刺激的反应，研究了这种抑制背后的机制。结果表明，对攀缘纤维和平行纤维进行短时间的联合刺激会导致平行纤维反应的长期抑制，并且如果在联合刺激期间抑制浦肯野细胞，则可以防止这种抑制。由于已证明抑制会缩短或消除由攀缘纤维冲动诱发的长期平台电位，因此这一发现支持了这样的假设，即攀缘纤维诱发的平台电位介导了平行纤维反应的异突触抑制。
