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相似文献

1
The torments of the cohesin ring.黏连蛋白环的折磨。
Nucleus. 2017 May 4;8(3):261-267. doi: 10.1080/19491034.2017.1295200. Epub 2017 Feb 27.
2
ATP hydrolysis is required for cohesin's association with chromosomes.黏连蛋白与染色体的结合需要ATP水解。
Curr Biol. 2003 Nov 11;13(22):1941-53. doi: 10.1016/j.cub.2003.10.036.
3
Evidence that loading of cohesin onto chromosomes involves opening of its SMC hinge.有证据表明，黏连蛋白加载到染色体上涉及到其SMC铰链的打开。
Cell. 2006 Nov 3;127(3):523-37. doi: 10.1016/j.cell.2006.08.048.
4
Impairing Cohesin Smc1/3 Head Engagement Compensates for the Lack of Eco1 Function.破坏黏连蛋白 Smc1/3 头部结合可补偿 Eco1 功能缺失。
Structure. 2016 Nov 1;24(11):1991-1999. doi: 10.1016/j.str.2016.09.001. Epub 2016 Sep 29.
5
ATP hydrolysis is required for relocating cohesin from sites occupied by its Scc2/4 loading complex.ATP 水解对于将黏连蛋白从其 Scc2/4 加载复合物占据的位点上重新定位是必需的。
Curr Biol. 2011 Jan 11;21(1):12-24. doi: 10.1016/j.cub.2010.12.004. Epub 2010 Dec 23.
6
Cohesin's ATPase activity is stimulated by the C-terminal Winged-Helix domain of its kleisin subunit.黏连蛋白的ATP酶活性由其kleisin亚基的C端翼状螺旋结构域刺激。
Curr Biol. 2006 Oct 24;16(20):1998-2008. doi: 10.1016/j.cub.2006.09.002.
7
Cohesin's ATPase activity couples cohesin loading onto DNA with Smc3 acetylation.黏连蛋白的ATP酶活性将黏连蛋白加载到DNA上的过程与Smc3乙酰化偶联起来。
Curr Biol. 2014 Oct 6;24(19):2228-37. doi: 10.1016/j.cub.2014.08.011. Epub 2014 Sep 11.
8
A model for ATP hydrolysis-dependent binding of cohesin to DNA.一种依赖ATP水解的黏连蛋白与DNA结合的模型。
Curr Biol. 2003 Nov 11;13(22):1930-40. doi: 10.1016/j.cub.2003.10.030.
9
Folding of cohesin's coiled coil is important for Scc2/4-induced association with chromosomes.着丝粒蛋白的卷曲螺旋的折叠对于 Scc2/4 诱导的与染色体的关联很重要。
Elife. 2021 Jul 14;10:e67268. doi: 10.7554/eLife.67268.
10
A Reversible Association between Smc Coiled Coils Is Regulated by Lysine Acetylation and Is Required for Cohesin Association with the DNA.赖氨酸乙酰化调节 Smc 卷曲螺旋的可逆缔合，这对于黏连蛋白与 DNA 的结合是必需的。
Mol Cell. 2016 Sep 15;63(6):1044-54. doi: 10.1016/j.molcel.2016.08.008. Epub 2016 Sep 8.

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Aging Dis. 2024 Feb 1;16(1):146-67. doi: 10.14336/AD.2024.0126.
2
Selected Genetic Factors Associated with Primary Ovarian Insufficiency.与原发性卵巢功能不全相关的部分遗传因素。
Int J Mol Sci. 2023 Feb 23;24(5):4423. doi: 10.3390/ijms24054423.
3
Primary ovarian insufficiency, meiosis and DNA repair.原发性卵巢功能不全、减数分裂和 DNA 修复。
Biomed J. 2020 Apr;43(2):115-123. doi: 10.1016/j.bj.2020.03.005. Epub 2020 May 4.
4
The Many Roles of Cohesin in Drosophila Gene Transcription.黏连蛋白在果蝇基因转录中的多种作用。
Trends Genet. 2019 Jul;35(7):542-551. doi: 10.1016/j.tig.2019.04.002. Epub 2019 May 23.

本文引用的文献

1
Structure of the cohesin loader Scc2.着丝粒复合物加载器 Scc2 的结构。
Nat Commun. 2017 Jan 6;8:13952. doi: 10.1038/ncomms13952.
2
Rapid movement and transcriptional re-localization of human cohesin on DNA.人类黏连蛋白在DNA上的快速移动和转录重新定位。
EMBO J. 2016 Dec 15;35(24):2671-2685. doi: 10.15252/embj.201695402. Epub 2016 Oct 31.
3
Crystal structure of the cohesin loader Scc2 and insight into cohesinopathy.黏连蛋白装载因子Scc2的晶体结构及对黏连蛋白病的见解
Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12444-12449. doi: 10.1073/pnas.1611333113. Epub 2016 Oct 18.
4
Impairing Cohesin Smc1/3 Head Engagement Compensates for the Lack of Eco1 Function.破坏黏连蛋白 Smc1/3 头部结合可补偿 Eco1 功能缺失。
Structure. 2016 Nov 1;24(11):1991-1999. doi: 10.1016/j.str.2016.09.001. Epub 2016 Sep 29.
5
A Reversible Association between Smc Coiled Coils Is Regulated by Lysine Acetylation and Is Required for Cohesin Association with the DNA.赖氨酸乙酰化调节 Smc 卷曲螺旋的可逆缔合，这对于黏连蛋白与 DNA 的结合是必需的。
Mol Cell. 2016 Sep 15;63(6):1044-54. doi: 10.1016/j.molcel.2016.08.008. Epub 2016 Sep 8.
6
Topology and structure of an engineered human cohesin complex bound to Pds5B.工程化人类黏连蛋白复合物与 Pds5B 结合的拓扑结构和结构。
Nat Commun. 2016 Aug 23;7:12523. doi: 10.1038/ncomms12523.
7
Structural Insights into Ring Formation of Cohesin and Related Smc Complexes.黏连蛋白及相关SMC复合物成环的结构解析
Trends Cell Biol. 2016 Sep;26(9):680-693. doi: 10.1016/j.tcb.2016.04.002. Epub 2016 Apr 28.
8
Single-Molecule Imaging Reveals a Collapsed Conformational State for DNA-Bound Cohesin.单分子成像揭示了与DNA结合的黏连蛋白的一种折叠构象状态。
Cell Rep. 2016 May 3;15(5):988-998. doi: 10.1016/j.celrep.2016.04.003. Epub 2016 Apr 21.
9
CTCF and Cohesin in Genome Folding and Transcriptional Gene Regulation.基因组折叠与转录基因调控中的CTCF和黏连蛋白
Annu Rev Genomics Hum Genet. 2016 Aug 31;17:17-43. doi: 10.1146/annurev-genom-083115-022339. Epub 2016 Apr 18.
10
Control of Smc Coiled Coil Architecture by the ATPase Heads Facilitates Targeting to Chromosomal ParB/parS and Release onto Flanking DNA.ATP酶头部对Smc卷曲螺旋结构的控制有助于靶向染色体ParB/parS并释放到侧翼DNA上。
Cell Rep. 2016 Mar 1;14(8):2003-16. doi: 10.1016/j.celrep.2016.01.066. Epub 2016 Feb 18.

黏连蛋白环的折磨。

The torments of the cohesin ring.

机构信息

a Bioinformatics Institute, A*STAR , Singapore.

b Institute of Molecular and Cell Biology, A*STAR , Singapore.

出版信息

Nucleus. 2017 May 4;8(3):261-267. doi: 10.1080/19491034.2017.1295200. Epub 2017 Feb 27.

DOI:10.1080/19491034.2017.1295200
PMID:28453390
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5499920/
Abstract

Cohesin is a ring-shaped protein complex which comprises the Smc1, Smc3 and Scc1 subunits. It topologically embraces chromosomal DNA to connect sister chromatids and stabilize chromatin loops. It is required for proper chromosomal segregation, DNA repair and transcriptional regulation. We have recently reported that cohesin rings can adopt a "collapsed" rod-like conformation which is driven by the interaction between the Smc1 and Smc3 coiled coil arms and is regulated by post-translational modifications. The "collapsed" conformation plays a role in cohesin ring assembly and its loading on the DNA. Here we speculate about the mechanism of cohesin's conformational transitions in relation to its loading on the DNA and draw parallels with other Smc-like complexes.

摘要

黏合蛋白是一种环形蛋白复合物，由 Smc1、Smc3 和 Scc1 亚基组成。它在拓扑结构上环绕染色体 DNA，连接姐妹染色单体并稳定染色质环。它对于正确的染色体分离、DNA 修复和转录调控是必需的。我们最近报道称，黏合蛋白环可以采用一种“塌陷”的杆状构象，这种构象是由 Smc1 和 Smc3 卷曲螺旋臂之间的相互作用驱动的，并受翻译后修饰的调节。“塌陷”构象在黏合蛋白环组装及其在 DNA 上的加载中发挥作用。在这里，我们推测黏合蛋白构象转变的机制与其在 DNA 上的加载有关，并与其他 Smc 样复合物进行类比。