HBeAg阴性患者队列中维生素D通路单核苷酸多态性与干扰素临床反应的关联
Association of vitamin D pathway SNPs and clinical response to interferon in a cohort of HBeAg-negative patients.
作者信息
Cusato Jessica, Boglione Lucio, De Nicolò Amedeo, Imbornone Rosaria, Cardellino Chiara Simona, Ghisetti Valeria, Carcieri Chiara, Cariti Giuseppe, Di Perri Giovanni, D'Avolio Antonio
机构信息
Department of Medical Sciences, Unit of Infectious Diseases, Amedeo di Savoia Hospital, University of Turin, Turin, Italy.
Laboratory of Microbiology & Virology, Department of Infectious Diseases, Amedeo di Savoia Hospital, Turin, Italy.
出版信息
Pharmacogenomics. 2017 May;18(7):651-661. doi: 10.2217/pgs-2016-0041. Epub 2017 Apr 28.
AIM
Vitamin D modulates biological processes; an influence of vitamin D levels and genetic variants was identified concerning hepatitis B virus infection. We evaluated the role of some SNPs of vitamin D pathway genes in some clinical features of hepatitis B affected patients treated with pegylated interferon.
METHODS
We investigated SNPs in IL-28B, CYP27B1, CYP27A1, CYP24A1, VDBP and VDR genes, through real-time PCR.
RESULTS
VDRApaI SNP was associated to viral load and HBsAg presence at different timings. In logistic regression analyses, VDRApaI AA genotype predicted baseline viral load >6 Log IU/ml (marker of nonresponse), and both virological and biochemical responses.
CONCLUSION
Pharmacogenetic data could help physicians in the prediction of patients with higher probability to achieve a good response.
目的
维生素D可调节生物过程；已确定维生素D水平和基因变异对乙型肝炎病毒感染有影响。我们评估了维生素D途径基因的一些单核苷酸多态性（SNP）在接受聚乙二醇化干扰素治疗的乙型肝炎患者某些临床特征中的作用。
方法
我们通过实时聚合酶链反应研究白细胞介素28B（IL-28B）、细胞色素P450 27B1（CYP27B1）、细胞色素P450 27A1（CYP27A1）、细胞色素P450 24A1（CYP24A1）、维生素D结合蛋白（VDBP）和维生素D受体（VDR）基因中的SNP。
结果
维生素D受体ApaI SNP在不同时间点与病毒载量和乙肝表面抗原（HBsAg）的存在相关。在逻辑回归分析中，维生素D受体ApaI AA基因型预测基线病毒载量>6 Log IU/ml（无反应标志物）以及病毒学和生化反应。
结论
药物遗传学数据可帮助医生预测更有可能获得良好反应的患者。
Zotero 插件