H2B单泛素化：诱导型增强子是否发生单泛素化
H2B monoubiquitination: t'ub or not t'ub for inducible enhancers.
作者信息
Segala Gregory, Picard Didier
机构信息
a Département de Biologie Cellulaire , Université de Genève , Genève , Switzerland.
出版信息
Transcription. 2017 Mar 15;8(2):126-132. doi: 10.1080/21541264.2017.1285852. Epub 2017 Feb 8.
Abstract
Recently, we reported the unexpected finding that the monoubiquitination of histone H2B (H2Bub1) regulates inducible enhancers. Here, we propose a conceptual framework to reconcile the apparently discrepant roles of H2Bub1 in transcription initiation and elongation, and we discuss how H2Bub1 could regulate cellular processes linked to non-coding transcription.
摘要
最近，我们报道了一个意外发现，即组蛋白H2B的单泛素化（H2Bub1）调控可诱导增强子。在此，我们提出一个概念框架，以协调H2Bub1在转录起始和延伸中明显相互矛盾的作用，并讨论H2Bub1如何调控与非编码转录相关的细胞过程。
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