Sferra T J, Pacini D L
Department of Pediatrics, Ohio State University, Columbus.
Pediatr Infect Dis J. 1988 Aug;7(8):552-6.
Mixed bacterial infection in meningitis is well-documented, but there have been few previous reports of mixed viral-bacterial meningitis. A retrospective analysis of the bacterial and viral cerebrospinal fluid (CSF) cultures from a 1-year period in a 315-bed children's hospital revealed 5 patients with mixed viral-bacterial meningitis among 276 patients with viral and/or bacterial culture-positive meningitis. These 5 accounted for 2.8% of the patients with positive CSF viral cultures and 4.8% of those with positive CSF bacterial cultures. All of the viruses were identified as enteroviruses, and the bacteria were Group B Streptococcus, Group D Salmonella, Streptococcus pneumoniae, Haemophilus influenzae type b and Staphylococcus aureus. The ages of the patients ranged from 10 days to 22 years. The clinical course of each of the illnesses was typical of bacterial meningitis. This relatively high frequency of mixed viral-bacterial meningitis could affect the utility of rapid viral diagnostic tests for CSF viruses.
脑膜炎中的混合细菌感染已有充分记录，但此前关于混合病毒 - 细菌脑膜炎的报道很少。对一家拥有315张床位的儿童医院1年期间的细菌和病毒脑脊液（CSF）培养物进行回顾性分析发现，在276例病毒和/或细菌培养阳性的脑膜炎患者中，有5例患有混合病毒 - 细菌脑膜炎。这5例占脑脊液病毒培养阳性患者的2.8%，占脑脊液细菌培养阳性患者的4.8%。所有病毒均被鉴定为肠道病毒，细菌为B组链球菌、D组沙门氏菌、肺炎链球菌、b型流感嗜血杆菌和金黄色葡萄球菌。患者年龄从10天至22岁不等。每种疾病的临床病程均为典型的细菌性脑膜炎。这种相对较高频率的混合病毒 - 细菌脑膜炎可能会影响脑脊液病毒快速诊断检测的效用。
