Díaz-Toro Felipe, Nazzal Nazal Carolina, Verdejo Hugo, Rossel VÍctor, Castro Pablo, Larrea Ricardo, Concepción Roberto, Sepúlveda Luis
Facultad de Enfermería, Escuela de Enfermería, Universidad Andrés Bello, Santiago, Chile.
Escuela de Salud Pública, Facultad de Medicina, Universidad de Chile, Santiago, Chile,
Rev Med Chil. 2017 Feb;145(2):164-171. doi: 10.4067/S0034-98872017000200003.
Frailty is a geriatric syndrome characterized by a progressive impairment in the subjects ability to respond to environmental stress. Frailty is more commonly found in heart failure (HF) patients than in general population and it is an independent predictor of rehospitalization, emergency room visits and death.
To estimate the prevalence of frailty in patients with decompensated HF admitted to four hospitals in Santiago, Chile.
Cross-sectional study. Subjects aged 60 or older consecutively admitted for decompensated HF to the study centers between August 2014 and March 2015 were included. Frailty was defined as the presence of three or more of the following criteria: unintended weight loss, muscular weakness, depression symptoms (exhaustion), reduced gait speed and low physical activity. Independent variables were tested for association using simple logistic regression. Variables associated with frailty (p < 0.05) were included in a multiple logistic regression model.
Seventy-nine subjects were included. The prevalence of frailty was 50.6%. Frail patients were mostly female (52.6%) and older than non-frail subjects (73.7± 7.9 vs 68.2 ± 7.1; p < 0.003). Independent predictors of frailty were age (Odds raio (OR) 1.10; 95% confidence intervals (CI): 1.03-1.17), quality of life measured with the Minnesota Living with Heart Failure Questionnaire (OR 1.07; IC95%: 1.03-1.11), previous hospitalizations (OR 2.56; 95%CI: 1.02-6.43) and number of medications (OR 4.46; 95%CI: 1.11-17.32).
The prevalence of frailty in patients admitted to the hospital for decompensated heart failure is high. Age, quality of life, hospitalizations and polypharmacy were factors associated with frailty in this group of participants.
衰弱是一种老年综合征，其特征是受试者应对环境压力的能力逐渐受损。与普通人群相比，衰弱在心力衰竭（HF）患者中更为常见，并且是再住院、急诊就诊和死亡的独立预测因素。
评估智利圣地亚哥四家医院收治的失代偿性HF患者的衰弱患病率。
横断面研究。纳入2014年8月至2015年3月期间连续入住研究中心的60岁及以上失代偿性HF患者。衰弱定义为存在以下三项或更多标准：非故意体重减轻、肌肉无力、抑郁症状（疲惫）、步速减慢和体力活动减少。使用简单逻辑回归检验自变量之间的关联。与衰弱相关的变量（p<0.05）纳入多重逻辑回归模型。
纳入79名受试者。衰弱患病率为50.6%。衰弱患者大多为女性（52.6%），且比非衰弱受试者年龄大（73.7±7.9岁对68.2±7.1岁；p<0.003）。衰弱的独立预测因素为年龄（比值比（OR）1.10；95%置信区间（CI）：1.03-1.17）、用明尼苏达心力衰竭生活问卷测量的生活质量（OR 1.07；95%CI：1.03-1.11）、既往住院史（OR 2.56；95%CI：1.02-6.43）和药物数量（OR 4.46；95%CI：1.11-17.32）。
因失代偿性心力衰竭入院患者的衰弱患病率很高。年龄、生活质量、住院史和多重用药是该组参与者中与衰弱相关的因素。
