CircosVCF：VCF文件中存储的全基因组序列变异的Circos可视化。

CircosVCF: circos visualization of whole-genome sequence variations stored in VCF files.

作者信息

Drori E, Levy D, Smirin-Yosef P, Rahimi O, Salmon-Divon M

机构信息

Agriculture and Oenology Research Department, Eastern R&D Center, 40700 Ariel, Israel.

Department of Molecular Biology, Ariel University, 40700 Ariel, Israel.

出版信息

Bioinformatics. 2017 May 1;33(9):1392-1393. doi: 10.1093/bioinformatics/btw834.

DOI:10.1093/bioinformatics/btw834

PMID:28453675

Abstract

SUMMARY

Visualization of whole-genomic variations in a meaningful manner assists researchers in gaining new insights into the underlying data, especially when it comes in the context of whole genome comparisons. CircosVCF is a web based visualization tool for genome-wide variant data described in VCF files, using circos plots. The user friendly interface of CircosVCF supports an interactive design of the circles in the plot, and the integration of additional information such as experimental data or annotations. The provided visualization capabilities give a broad overview of the genomic relationships between genomes, and allow identification of specific meaningful SNPs regions.

AVAILABILITY AND IMPLEMENTATION

CircosVCF was implemented in JavaScript and is available at http://www.ariel.ac.il/research/fbl/software.

CONTACT

malisa@ariel.ac.il.

SUPPLEMENTARY INFORMATION

Supplementary data are available at Bioinformatics online.

摘要

以有意义的方式可视化全基因组变异有助于研究人员对基础数据获得新的见解，尤其是在全基因组比较的背景下。CircosVCF是一个基于网络的可视化工具，用于使用Circos图展示VCF文件中描述的全基因组变异数据。CircosVCF用户友好的界面支持对图中圆圈进行交互式设计，并能整合实验数据或注释等附加信息。所提供的可视化功能能全面概述基因组之间的基因组关系，并允许识别特定的有意义的单核苷酸多态性（SNP）区域。