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Herpes Simplex Virus Type 2 Acquisition Among HIV-1-Infected Adults Treated With Tenofovir Disoproxyl Fumarate as Part of Combination Antiretroviral Therapy: Results From the ACTG A5175 PEARLS Study.接受替诺福韦酯富马酸盐治疗的HIV-1感染成人中2型单纯疱疹病毒感染情况：ACTG A5175 PEARLS研究结果，该治疗为联合抗逆转录病毒疗法的一部分
J Infect Dis. 2017 Mar 15;215(6):907-910. doi: 10.1093/infdis/jix029.
2
Daily oral tenofovir and emtricitabine-tenofovir preexposure prophylaxis reduces herpes simplex virus type 2 acquisition among heterosexual HIV-1-uninfected men and women: a subgroup analysis of a randomized trial.每日口服替诺福韦和恩曲他滨替诺福韦预防暴露前用药可降低 HIV-1 未感染的异性恋男性和女性中单纯疱疹病毒 2 型的感染率：一项随机试验的亚组分析。
Ann Intern Med. 2014 Jul 1;161(1):11-9. doi: 10.7326/M13-2471.
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Tenofovir Gel for Prevention of Herpes Simplex Virus Type 2 Acquisition: Findings From the VOICE Trial.替诺福韦凝胶预防单纯疱疹病毒 2 型感染：VOICE 试验结果。
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Daily oral emtricitabine/tenofovir preexposure prophylaxis and herpes simplex virus type 2 among men who have sex with men.每日口服恩曲他滨/替诺福韦暴露前预防与男男性行为者中的2型单纯疱疹病毒
PLoS One. 2014 Mar 17;9(3):e91513. doi: 10.1371/journal.pone.0091513. eCollection 2014.
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No impact of oral tenofovir disoproxil fumarate on herpes simplex virus shedding in HIV-infected adults.口服替诺福韦二吡呋酯对 HIV 感染成人单纯疱疹病毒脱落无影响。
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Oral and Vaginal Tenofovir for Genital Herpes Simplex Virus Type 2 Shedding in Immunocompetent Women: A Double-Blind, Randomized, Cross-over Trial.口服和阴道用替诺福韦治疗免疫功能正常女性的单纯疱疹病毒2型生殖器排毒：一项双盲、随机、交叉试验。
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The Vaginal Acquisition and Dissemination of HIV-1 Infection in a Novel Transgenic Mouse Model Is Facilitated by Coinfection with Herpes Simplex Virus 2 and Is Inhibited by Microbicide Treatment.在一种新型转基因小鼠模型中，单纯疱疹病毒2合并感染促进了HIV-1感染的阴道获取和传播，而杀菌剂治疗则对其具有抑制作用。
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Differential Mechanisms of Tenofovir and Tenofovir Disoproxil Fumarate Cellular Transport and Implications for Topical Preexposure Prophylaxis.替诺福韦和富马酸替诺福韦二吡呋酯细胞转运的差异机制及其对局部暴露前预防的意义
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Impact of herpes simplex virus type 2 on HIV-1 acquisition and progression in an HIV vaccine trial (the Step study).单纯疱疹病毒 2 型对 HIV 疫苗试验（Step 研究）中 HIV-1 获得和进展的影响。
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Tenofovir, Another Inexpensive, Well-Known and Widely Available Old Drug Repurposed for SARS-COV-2 Infection.替诺福韦，另一种用于治疗新型冠状病毒肺炎的价格低廉、广为人知且易于获取的老药新用。
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本文引用的文献

1
Tenofovir Gel for the Prevention of Herpes Simplex Virus Type 2 Infection.用于预防2型单纯疱疹病毒感染的替诺福韦凝胶
N Engl J Med. 2015 Aug 6;373(6):530-9. doi: 10.1056/NEJMoa1410649.
2
Oral and Vaginal Tenofovir for Genital Herpes Simplex Virus Type 2 Shedding in Immunocompetent Women: A Double-Blind, Randomized, Cross-over Trial.口服和阴道用替诺福韦治疗免疫功能正常女性的单纯疱疹病毒2型生殖器排毒：一项双盲、随机、交叉试验。
J Infect Dis. 2015 Dec 15;212(12):1949-56. doi: 10.1093/infdis/jiv317. Epub 2015 Jun 4.
3
Psychosocial predictors of non-adherence and treatment failure in a large scale multi-national trial of antiretroviral therapy for HIV: data from the ACTG A5175/PEARLS trial.在一项针对HIV的抗逆转录病毒疗法的大规模多国试验中，不依从和治疗失败的社会心理预测因素：来自ACTG A5175/PEARLS试验的数据。
PLoS One. 2014 Aug 25;9(8):e104178. doi: 10.1371/journal.pone.0104178. eCollection 2014.
4
Daily oral tenofovir and emtricitabine-tenofovir preexposure prophylaxis reduces herpes simplex virus type 2 acquisition among heterosexual HIV-1-uninfected men and women: a subgroup analysis of a randomized trial.每日口服替诺福韦和恩曲他滨替诺福韦预防暴露前用药可降低 HIV-1 未感染的异性恋男性和女性中单纯疱疹病毒 2 型的感染率：一项随机试验的亚组分析。
Ann Intern Med. 2014 Jul 1;161(1):11-9. doi: 10.7326/M13-2471.
5
Daily oral emtricitabine/tenofovir preexposure prophylaxis and herpes simplex virus type 2 among men who have sex with men.每日口服恩曲他滨/替诺福韦暴露前预防与男男性行为者中的2型单纯疱疹病毒
PLoS One. 2014 Mar 17;9(3):e91513. doi: 10.1371/journal.pone.0091513. eCollection 2014.
6
Efficacy and safety of three antiretroviral regimens for initial treatment of HIV-1: a randomized clinical trial in diverse multinational settings.三种抗逆转录病毒方案治疗 HIV-1 初治的疗效和安全性：多种族多国环境下的随机临床试验。
PLoS Med. 2012;9(8):e1001290. doi: 10.1371/journal.pmed.1001290. Epub 2012 Aug 14.
7
Antiretroviral prophylaxis for HIV prevention in heterosexual men and women.抗逆转录病毒预防治疗用于异性恋男性和女性的 HIV 预防。
N Engl J Med. 2012 Aug 2;367(5):399-410. doi: 10.1056/NEJMoa1108524. Epub 2012 Jul 11.
8
Infectious co-factors in HIV-1 transmission herpes simplex virus type-2 and HIV-1: new insights and interventions.1型人类免疫缺陷病毒传播中的感染性辅助因素——2型单纯疱疹病毒与1型人类免疫缺陷病毒：新见解与干预措施
Curr HIV Res. 2012 Apr;10(3):228-37. doi: 10.2174/157016212800618156.
9
Topical tenofovir, a microbicide effective against HIV, inhibits herpes simplex virus-2 replication.局部用替诺福韦，一种针对 HIV 有效的杀微生物剂，可抑制单纯疱疹病毒 2 型的复制。
Cell Host Microbe. 2011 Oct 20;10(4):379-89. doi: 10.1016/j.chom.2011.08.015.
10
No impact of oral tenofovir disoproxil fumarate on herpes simplex virus shedding in HIV-infected adults.口服替诺福韦二吡呋酯对 HIV 感染成人单纯疱疹病毒脱落无影响。
AIDS. 2011 Jan 14;25(2):207-10. doi: 10.1097/QAD.0b013e328341ddf7.

接受替诺福韦酯富马酸盐治疗的HIV-1感染成人中2型单纯疱疹病毒感染情况：ACTG A5175 PEARLS研究结果，该治疗为联合抗逆转录病毒疗法的一部分

Herpes Simplex Virus Type 2 Acquisition Among HIV-1-Infected Adults Treated With Tenofovir Disoproxyl Fumarate as Part of Combination Antiretroviral Therapy: Results From the ACTG A5175 PEARLS Study.

作者信息

Celum Connie, Hong Ting, Cent Anne, Donnell Deborah, Morrow Rhoda, Baeten Jared M, Firnhaber Cynthia, Grinsztejn Beatriz, Hosseinipour Mina C, Lalloo Umesh, Nyirenda Mulinda, Riviere Cynthia, Sanchez Jorge, Santos Breno, Supparatpinyo Khuanchai, Hakim James, Kumarasamy N, Campbell Thomas B

机构信息

Department of Global Health, University of Washington , Seattle, Washington, USA.

Department of Medicine, University of Washington , Seattle, Washington, USA.

出版信息

J Infect Dis. 2017 Mar 15;215(6):907-910. doi: 10.1093/infdis/jix029.

DOI:10.1093/infdis/jix029
PMID:28453835
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5406847/
Abstract

OBJECTIVE

Tenofovir disoproxyl fumarate (TDF) disoproxyl fumarate (TDF) has in vitro activity against herpes simplex virus type 2 (HSV-2) and reduced HSV-2 acquisition as preexposure prophylaxis. Whether TDF-containing antiretroviral therapy (ART) reduces HSV-2 acquisition is unknown.

DESIGN

Secondary analysis of AIDS Clinical Trials Group A5175, a randomized, open-label study of 3 ART regimens among 1571 participants.

METHODS

HSV-2 serostatus was assessed at baseline, at study exit, and before a change in ART regimen.

RESULTS

Of 365 HSV-2-seronegative persons, 68 acquired HSV-2, with 24 receiving TDF-containing ART and 44 receiving ART without TDF (HSV-2 seroconversion incidence, 6.42 and 6.63 cases/100 person-years, respectively; hazard ratio, 0.89; 95% confidence interval, .55-1.44).

CONCLUSIONS

HSV-2 acquisition was not reduced in HIV-infected, HSV-2-uninfected persons during TDF-containing ART.

摘要

目的

替诺福韦酯（TDF）对2型单纯疱疹病毒（HSV-2）具有体外活性，并且作为暴露前预防可降低HSV-2感染率。含TDF的抗逆转录病毒疗法（ART）是否能降低HSV-2感染率尚不清楚。

设计

对艾滋病临床试验组A5175进行二次分析，这是一项针对1571名参与者的3种ART方案的随机、开放标签研究。

方法

在基线、研究结束时以及ART方案改变之前评估HSV-2血清学状态。

结果

在365名HSV-2血清阴性者中，68人感染了HSV-2，其中24人接受含TDF的ART治疗，44人接受不含TDF的ART治疗（HSV-2血清转换发生率分别为6.42例/100人年和6.63例/100人年；风险比为0.89；95%置信区间为0.55-1.44）。

结论

在接受含TDF的ART治疗的HIV感染且HSV-2未感染的人群中，HSV-2感染率并未降低。