Singh Abhishek K, Thota Bala N S, Schade Boris, Achazi Katharina, Khan Abdullah, Böttcher Christoph, Sharma Sunil K, Haag Rainer
Department of Chemistry, University of Delhi, Delhi, India.
Institut für Chemie und Biochemie, Freie Universität Berlin, Takustraße 3, 14195, Berlin, Germany.
Chem Asian J. 2017 Jul 18;12(14):1796-1806. doi: 10.1002/asia.201700450. Epub 2017 Jun 9.
A new class of twinned amphiphiles was developed by conjugating a pair of hydrophilic head groups from mPEG chains (M : 350 or 1000) and a pair of hydrophobic segments from linear alkyl chains (C or C ) through a novel spacer synthesized from glycerol and p-hydroxybenzoic acid. The aggregation phenomena of the amphiphiles were proven by DLS and fluorescence experiments, whereas size and morphology of the aggregates were evaluated by cryo-TEM. The measurements proved the formation of globular, thread-like or rod-like micelles as well as planar double-layer assemblies, depending on the amphiphile's molecular structure. The applicability of these non-ionic amphiphilic systems as nanocarriers for hydrophobic guest molecules was demonstrated by encapsulating a hydrophobic dye, Nile Red, and a hydrophobic drug, Nimodipine. The transport capacity results for both Nimodipine and Nile Red prove them as a promising candidate for drug delivery.
通过由甘油和对羟基苯甲酸合成的新型间隔基，将一对来自甲氧基聚乙二醇链（M：350或1000）的亲水头基与一对来自线性烷基链（C或C）的疏水链段共轭，开发了一类新的孪联两亲分子。通过动态光散射（DLS）和荧光实验证明了两亲分子的聚集现象，而通过冷冻透射电子显微镜（cryo-TEM）评估了聚集体的大小和形态。测量结果证明，根据两亲分子的分子结构，会形成球状、线状或棒状胶束以及平面双层聚集体。通过包封疏水性染料尼罗红和疏水性药物尼莫地平，证明了这些非离子两亲体系作为疏水性客体分子纳米载体的适用性。尼莫地平和尼罗红的转运能力结果证明它们是药物递送的有前景的候选物。
