Mittal Ayushi, Singh Abhishek K, Achazi Katharina, Nie Chuanxiong, Haag Rainer, Sharma Sunil K
Department of Chemistry, University of Delhi Delhi 110 007 India
Institut für Chemie und Biochemie, Freie Universität Berlin Takustraße 3 14195 Berlin Germany.
RSC Adv. 2020 Oct 12;10(61):37555-37563. doi: 10.1039/d0ra07392j. eCollection 2020 Oct 7.
A new class of non-ionic amphiphiles is synthesized using a diaryl derivative of diglycerol as a central core and functionalizing it with long alkyl chains (C-12/C-15) and monomethoxy PEG moiety ( : 350/550) by following a chemo-enzymatic approach. The aggregation behavior of the amphiphiles in aqueous medium is studied by using dynamic light scattering (DLS) and fluorescence spectroscopy, whereas the size and morphology of the aggregates are studied by transmission electron microscopy (TEM). A hydrophobic dye, Nile red and a hydrophobic drug, nimodipine, are used to demonstrate the nano-carrier capability of these non-ionic amphiphilic systems and the results are compared with amphiphilic analogues obtained from the triaryl derivatives of triglycerol. The controlled release of the encapsulated dye is successfully carried out in the presence of immobilized lipase (Novozym 435). Furthermore, cytotoxicity data is also collected which suggests that the amphiphiles are suitable for biomedical applications.
使用二甘油的二芳基衍生物作为中心核，通过化学酶法用长烷基链（C-12/C-15）和单甲氧基聚乙二醇部分（：350/550）对其进行功能化，合成了一类新型的非离子两亲物。通过动态光散射（DLS）和荧光光谱研究两亲物在水性介质中的聚集行为，而通过透射电子显微镜（TEM）研究聚集体的尺寸和形态。使用疏水性染料尼罗红和疏水性药物尼莫地平来证明这些非离子两亲系统的纳米载体能力，并将结果与从甘油三酯的三芳基衍生物获得的两亲类似物进行比较。在固定化脂肪酶（诺维信435）存在下成功实现了包封染料的控释。此外，还收集了细胞毒性数据，表明两亲物适用于生物医学应用。
