Raible L H
Department of Psychology, Kalamazoo College, MI 49007.
Pharmacol Biochem Behav. 1988 May;30(1):37-43. doi: 10.1016/0091-3057(88)90422-4.
Alpha-melanocyte stimulating hormone (MSH) has been found to exert a short- and a long-term inhibitory action on lordosis. The present series of experiments examined the possibility that these effects are mediated by MSH-induced alterations in activity at serotonin type II receptors. In Experiment 1, quipazine (serotonin type II agonist) was found to significantly attenuate the short-term effect of MSH while only partially attenuating the long-term action of MSH. In the second experiment, doses of MSH and of pirenperone (serotonin type II antagonist) that did not inhibit lordotic responding when administered alone were found to inhibit responding when administered together. It was also found that 20 ng MSH produced a long-term, but not a short-term inhibition of receptivity. The results of Experiment 3 indicated that the inhibition observed in Experiment 2 could be reversed by quipazine. These results suggest that alterations in serotonin activity are one mechanism by which the effects of MSH are produced. The relevance of this to the regulation of reproductive states is discussed.
α-黑素细胞刺激素（MSH）已被发现对脊柱前凸具有短期和长期抑制作用。本系列实验研究了这些作用是否由MSH诱导的5-羟色胺II型受体活性改变介导。在实验1中，发现喹哌嗪（5-羟色胺II型激动剂）能显著减弱MSH的短期作用，而仅部分减弱MSH的长期作用。在第二个实验中，单独给药时不抑制脊柱前凸反应的MSH和匹仑哌隆（5-羟色胺II型拮抗剂）剂量，当一起给药时被发现能抑制反应。还发现20纳克MSH产生长期但非短期的接受性抑制。实验3的结果表明，实验2中观察到的抑制作用可被喹哌嗪逆转。这些结果表明，5-羟色胺活性改变是产生MSH作用的一种机制。并讨论了这与生殖状态调节的相关性。
