Thody A J, Wilson C A
Physiol Behav. 1983 Jul;31(1):67-72. doi: 10.1016/0031-9384(83)90097-5.
When administered to ovariectomized females, primed with oestradiol benzoate (OB) and progesterone, alpha-MSH increased lordosis behaviour in those rats that showed a low level of receptivity but in rats that were receptive it had an inhibitory effect. alpha-Melanocyte stimulating hormone also inhibited proceptive behaviour in these females. Luteinizing hormone releasing hormone (LHRH), on the other hand, failed to have a similar inhibiting effect although it did stimulate lordosis. While adrenalectomy failed to alter the stimulatory effect of alpha-MSH on lordosis it completely prevented the inhibitory actions of alpha-MSH on both lordosis and proceptive behaviour. Thus, while alpha-MSH may stimulate lordosis through a central action its inhibitory effects on lordosis and proceptive behaviour are probably mediated via the adrenal glands. Although alpha-MSH may stimulate the secretion of an adrenal steroid that blocks the facilitatory action of progesterone on female sexual behaviour the present results suggest that this inhibitory effect could be mediated by a catecholamine.
给用苯甲酸雌二醇（OB）和孕酮预处理的去卵巢雌性大鼠注射α-促黑素细胞激素（α-MSH）后，在那些接受性水平较低的大鼠中，α-MSH增加了脊柱前凸行为，但在有接受性的大鼠中，它具有抑制作用。α-促黑素细胞激素也抑制了这些雌性大鼠的求偶行为。另一方面，促黄体生成激素释放激素（LHRH）虽然确实刺激了脊柱前凸，但未能产生类似的抑制作用。虽然肾上腺切除术未能改变α-MSH对脊柱前凸的刺激作用，但它完全阻止了α-MSH对脊柱前凸和求偶行为的抑制作用。因此，虽然α-MSH可能通过中枢作用刺激脊柱前凸，但其对脊柱前凸和求偶行为的抑制作用可能是通过肾上腺介导的。虽然α-MSH可能刺激一种肾上腺类固醇的分泌，该类固醇会阻断孕酮对雌性性行为的促进作用，但目前的结果表明，这种抑制作用可能是由儿茶酚胺介导的。
