Panelli Santos Karina Cecília Panelli, Matsuzaki Hidenobu, Unetsubo Teruhisa, Tsuyoshi Shimo, Nagatsuka Hitoshi, Asaumi Jun-Ichi
Department of Oral and Maxillofacial Radiology, Field of Tumor Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kita-ku, Okayama 700-8558, Japan.
Department of Oral Diagnosis and Dentomaxillofacial Radiology, Okayama University Hospital, Kita-ku, Okayama 700-8558, Japan.
Oncol Lett. 2017 Apr;13(4):2679-2683. doi: 10.3892/ol.2017.5783. Epub 2017 Feb 28.
Salivary gland carcinomas are rare tumors, representing ~0.5% of all malignancies. Myoepithelioma is also uncommon, representing ~1% of all salivary gland tumors. Myoepithelial carcinoma (MC) is even rarer, representing 0.2 to 0.6% of all salivary gland tumors. We herein report a case of MC with multiple metastases arising from a submandibular gland in a 71-year-old male patient and present the associated imaging findings. The patient was considered to have a de novo type of myoepithelial carcinoma, which is reportedly associated with higher malignancy than the transformation type of the disease (i.e., a malignant change from pleomorphic adenoma or myoepithelioma). This was reflected in the multiple lung and bone metastases sites and strong positivity for p53 and Ki-67.
涎腺癌是罕见肿瘤，约占所有恶性肿瘤的0.5%。肌上皮瘤也不常见，约占所有涎腺肿瘤的1%。肌上皮癌（MC）更为罕见，占所有涎腺肿瘤的0.2%至0.6%。我们在此报告一例71岁男性患者下颌下腺来源的伴有多发转移的肌上皮癌病例，并展示相关影像学表现。该患者被认为是新发类型的肌上皮癌，据报道这种类型比疾病的转化型（即多形性腺瘤或肌上皮瘤的恶性变）具有更高的恶性程度。这体现在多发的肺和骨转移部位以及p53和Ki-67的强阳性表达上。
