Dolka Izabella, Gruk-Jurka Anna, Jurka Piotr, Dolka Beata, Bonecka Joanna
Department of Pathology and Veterinary Diagnostics, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 159c, 02-776, Warsaw, Poland.
Department of Small Animal Diseases with Clinic, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 159c, 02-776, Warsaw, Poland.
Acta Vet Scand. 2017 Apr 28;59(1):25. doi: 10.1186/s13028-017-0294-z.
Hyaline ring granuloma (HRG) is an uncommon histopathologic finding of unsolved etiopathogenesis. According to the exogenous theory, HRG develops due to implantation of foreign material, most probably indigestible plant fragments. HRG is a comparatively rare condition in humans, mostly involving the oral cavity with very rare extraoral locations.
An 1-year-old mixed-breed dog in good condition was presented for routine ovariohysterectomy. Disseminated HGR were accidentally found in the omental adipose tissue during surgery. Histopathology revealed the presence of ring-like hyaline structures surrounded by granulomatous inflammation including foreign body-type multinucleated giant cells. The histochemical examinations indicated the exogenous plant origin of the foreign material.
The lesions were similar to the findings in humans with HRG. The definitive diagnosis remains largely based on histopathological examination supported by special histochemical stains. To the best of our knowledge, this is the first case of hyaline ring granuloma reported in a non-human species. Moreover, the omentum is an uncommon location for this condition.
透明环肉芽肿（HRG）是一种病因未明的罕见组织病理学表现。根据外源性理论，HRG是由于异物植入引起的，最有可能是难以消化的植物碎片。HRG在人类中相对罕见，主要累及口腔，口腔外部位非常少见。
一只1岁健康的混血犬因常规卵巢子宫切除术前来就诊。手术中意外在网膜脂肪组织中发现了弥漫性HGR。组织病理学显示存在环状透明结构，周围有肉芽肿性炎症，包括异物型多核巨细胞。组织化学检查表明异物来源于外源性植物。
这些病变与人类HRG的表现相似。明确诊断主要仍基于组织病理学检查，并辅以特殊组织化学染色。据我们所知，这是首次在非人类物种中报道透明环肉芽肿病例。此外，网膜是这种情况的罕见发病部位。
