Liu Qianying, Lei Zhixin, Cui Luqing, Zhang Jianwu, Awais Ihsan, Dai Menghong, Wang Xu, Yuan Zonghui
National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Wuhan, Hubei 430070, China.
MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
Regul Toxicol Pharmacol. 2017 Jul;87:9-22. doi: 10.1016/j.yrtph.2017.04.011. Epub 2017 Apr 25.
To investigate the potential carcinogenicity of cyadox, an antimicrobial agent, four groups of Sprague-Dawley rats (50 rats/sex/group) were fed diets containing cyadox (0, 200, 600 or 2000 mg/kg) for up to two years. There were significant decreases in body weight, feed intake and feed efficiency in both genders during most of the period in the 2000 mg/kg group. Significant decreases in serum ALT were observed in the 2000 mg/kg group at weeks 52, 78 and 104. For the control, 200, 600, and 2000 mg/kg groups, the tumor incidence in females was 33.3%, 37.2%, 40.0% and 19.0%, while it in males it was 18.9%, 2.6%, 17.1% and 13.6%, respectively. At histopathology, no increases in tumor incidence were attributed to treatment with cyadox. The mild swelling and fatty degeneration in hepatocytes, and mild swelling and tubular necrosis in the kidney were observed in 2000 mg/kg group. The no-observed-effect-level (NOEL) for carcinogenicity of cyadox fed to rats was 2000 mg/kg diet (132.18-156.28 mg/kg b.w./day). In conclusion, cyadox was not carcinogenic to rats with the liver and kidney as the target organs, and the side chain may be involved in toxicity and carcinogenicity mediated by QdNOs.
为研究抗菌剂喹乙醇的潜在致癌性，将四组斯普拉格-道利大鼠（每组50只，雌雄各半）喂食含喹乙醇（0、200、600或2000毫克/千克）的饲料，持续两年。在2000毫克/千克组的大部分时间里，雌雄大鼠的体重、采食量和饲料效率均显著下降。在第52、78和104周时，2000毫克/千克组的血清谷丙转氨酶显著下降。对照组、200、600和2000毫克/千克组中，雌性大鼠的肿瘤发生率分别为33.3%、37.2%、40.0%和19.0%，雄性大鼠的肿瘤发生率分别为18.9%、2.6%、17.1%和13.6%。组织病理学检查显示，喹乙醇处理并未导致肿瘤发生率增加。在2000毫克/千克组中观察到肝细胞轻度肿胀和脂肪变性，以及肾脏轻度肿胀和肾小管坏死。喹乙醇对大鼠致癌性的未观察到有害作用水平（NOEL）为2000毫克/千克饲料（132.18 - 156.28毫克/千克体重/天）。总之，喹乙醇对以肝脏和肾脏为靶器官的大鼠无致癌性，其侧链可能参与了由喹烯酮介导的毒性和致癌性。
