Wang Xu, Zhou Wen, Ihsan Awais, Chen Dongmei, Cheng Guyue, Hao Haihong, Liu Zhenli, Wang Yulian, Yuan Zonghui
National Reference Laboratory of Veterinary Drug Residues (HZAU) and MOA Key Laboratory for Detection of Veterinary Drug Residues, China.
MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
Regul Toxicol Pharmacol. 2015 Nov;73(2):652-9. doi: 10.1016/j.yrtph.2015.09.023. Epub 2015 Sep 25.
Cyadox (2-formylquinoxaline-N(1),N(4)-dioxide cyanocetylhydrazone) is a new antimicrobial agent and growth-promoter to be used in food-producing animals. Although its toxicity has been clearly documented in rodents, no study is available in non-rodent animals. Therefore, we studied the subchronic effects of cyadox in Beagle dogs to provide additional information with which to establish safety criteria for human exposure. For this purpose, 36 Beagle dogs, 18 males and 18 females, were divided into four groups and fed diets containing 0, 100, 450 and 2500 mg/kg of cyadox, respectively, for 13 weeks. It was found that there were no significant changes among the examined parameters, except for an increase in the level of serum potassium (K(+)) in 2500 mg/kg cyadox group in males at week 13 of the study. However, the K(+) level returned to normal during the recovery period. In conclusion, cyadox showed slight effects in Beagle dogs in the subchronic oral toxicity study. The no-observed-adverse-effect level of cyadox was considered to be 450 mg/kg diet, which equates to approximately 15.3-15.4 mg/kg b.w./day. The study provided subchronic effects of cyadox in Beagle dogs, suggesting that cyadox might present mild toxicity in non-rodents.
喹赛多（2-甲酰基喹喔啉-N(1),N(4)-二氧化物氰乙酰腙）是一种用于食用动物的新型抗菌剂和生长促进剂。尽管其毒性在啮齿动物中已有明确记录，但在非啮齿动物中尚无相关研究。因此，我们研究了喹赛多对比格犬的亚慢性影响，以提供更多信息来建立人类接触的安全标准。为此，将36只比格犬（18只雄性和18只雌性）分为四组，分别喂食含0、100、450和2500 mg/kg喹赛多的日粮，持续13周。结果发现，除了在研究第13周时，2500 mg/kg喹赛多组雄性犬的血清钾（K(+)）水平升高外，所检测的参数之间没有显著变化。然而，在恢复期钾水平恢复正常。总之，在亚慢性经口毒性研究中，喹赛多对比格犬显示出轻微影响。喹赛多的未观察到不良反应水平被认为是450 mg/kg日粮，相当于约15.3 - 15.4 mg/kg体重/天。该研究提供了喹赛多对比格犬的亚慢性影响，表明喹赛多在非啮齿动物中可能具有轻度毒性。
