Biochemistry Division, Chemistry Department, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt.
Inflammopharmacology. 2023 Jun;31(3):1183-1198. doi: 10.1007/s10787-023-01178-0. Epub 2023 Mar 30.
Psoriasis represents an immune-mediated disease with an unclear cause that's marked by inflammation triggered by dysfunction in the immune system, which results in inflammation in various parts of the skin. There could be obvious symptoms, such as elevated plaques; these plaques may appear differently depending on the type of skin. This disease can cause inflammation in the elbows, lower back, scalp, knees, or other regions of the body. It can begin at any age, although it most commonly affects individuals between the ages of 50 and 60. Specific cells (such as T cells) have been observed to play an obvious role in the pathogenesis of psoriasis, in addition to specific immunological molecules such as TNF-, IL-12, IL-23, IL-17, and other molecules that can aid in the pathogenesis of psoriasis. So, during the past two decades, biologists have created chemical drugs that target these cells or molecules and therefore prevent the disease from occurring. Alefacept, efalizumab, Adalimumab, Ustekinumab, and Secukinumab are a few examples of chemical drugs. It was discovered that these chemical drugs have long-term side effects that can cause defects in the patient's body, such as the development of the rare but life-threatening disorder progressive multifocal leukoencephalopathy (PCL). Its rapidly progressive infection of the central nervous system caused by the JC virus and other drugs may cause increased production of neutralising anti-drug antibodies (ADA) and the risk of infusion reactions like pruritus, flushing, hypertension, headache, and rash. So, our context intends to talk in our review about natural products or plants that may have therapeutic characteristics for this disease and may have few or no side effects on the patient's body.
银屑病是一种免疫介导的疾病，其病因尚不清楚，其特征是免疫系统功能障碍引发的炎症，导致皮肤的各个部位发生炎症。可能有明显的症状，如升高的斑块；这些斑块可能因皮肤类型而异而有所不同。这种疾病可引起肘部、下背部、头皮、膝盖或身体其他部位的炎症。它可以在任何年龄开始，但最常见于 50 至 60 岁之间的个体。除了 TNF-、IL-12、IL-23、IL-17 等特定免疫分子外，特定细胞（如 T 细胞）在银屑病的发病机制中也明显发挥作用，这些分子有助于银屑病的发病机制。因此，在过去的二十年中，生物学家已经开发出针对这些细胞或分子的化学药物，从而预防疾病的发生。阿法赛普特、依法利珠单抗、阿达木单抗、乌司奴单抗和司库奇尤单抗就是一些化学药物的例子。人们发现这些化学药物有长期的副作用，可能会导致患者身体出现缺陷，例如罕见但危及生命的进行性多灶性白质脑病（PCL）的发展。其由 JC 病毒和其他药物引起的中枢神经系统的快速进展性感染，可能导致中和性抗药物抗体（ADA）的产生增加，并可能引发瘙痒、潮红、高血压、头痛和皮疹等输注反应。因此，我们的研究旨在讨论天然产物或植物可能对这种疾病具有治疗特性，并且对患者的身体可能只有很少或没有副作用。
