Kulick Erin R, Wellenius Gregory A, Kaufman Joel D, DeRosa Janet T, Kinney Patrick L, Cheung Ying Kuen, Wright Clinton B, Sacco Ralph L, Elkind Mitchell S
From the Department of Epidemiology, Mailman School of Public Health (E.R.K., M.S.E.), Department of Neurology, College of Physicians and Surgeons (E.R.K., J.T.D., M.S.E.), and Department of Biostatistics, Mailman School of Public Health (Y.K.C.), Columbia University, New York, NY; Department of Epidemiology, Brown University School of Public Health, Providence, RI (G.A.W.); Department of Environmental and Occupational Health Sciences, University of Washington School of Public Health, Seattle (J.D.K.); Department of Environmental Health, Boston University School of Public Health, MA (P.L.K.); and Departments of Neurology, Public Health Sciences, and Human Genetics, Miller School of Medicine, University of Miami, FL (C.B.W., R.L.S.).
Stroke. 2017 Jul;48(7):1966-1968. doi: 10.1161/STROKEAHA.117.016672. Epub 2017 Apr 28.
Long-term exposure to ambient air pollution is associated with higher risk of cardiovascular disease and stroke. We hypothesized that long-term exposure to air pollution would be associated with magnetic resonance imaging markers of subclinical cerebrovascular disease.
Participants were 1075 stroke-free individuals aged ≥50 years drawn from the magnetic resonance imaging subcohort of the Northern Manhattan Study who had lived at the same residence for at least 2 years before magnetic resonance imaging. Cross-sectional associations between ambient air pollution and subclinical cerebrovascular disease were analyzed.
We found an association between distance to roadway, a proxy for residential exposure to traffic pollution, and white matter hyperintensity volume; however, after adjusting for risk factors, this relationship was no longer present. All other associations between pollutant measures and white matter hyperintensity volume were null. There was no clear association between exposure to air pollutants and subclinical brain infarcts or total cerebral brain volume.
We found no evidence that long-term exposure to ambient air pollution is independently associated with subclinical cerebrovascular disease in an urban population-based cohort.
长期暴露于环境空气污染中与心血管疾病和中风的较高风险相关。我们推测，长期暴露于空气污染中会与亚临床脑血管疾病的磁共振成像标志物相关。
研究对象为1075名年龄≥50岁且无中风的个体，他们来自北曼哈顿研究的磁共振成像亚队列，在进行磁共振成像前至少已在同一住所居住2年。分析了环境空气污染与亚临床脑血管疾病之间的横断面关联。
我们发现距离道路的远近（这是居住环境暴露于交通污染的一个指标）与白质高信号体积之间存在关联；然而，在对危险因素进行校正后，这种关系不再存在。污染物测量值与白质高信号体积之间的所有其他关联均无统计学意义。暴露于空气污染物与亚临床脑梗死或全脑体积之间没有明显关联。
我们没有发现证据表明，在以城市人群为基础的队列中，长期暴露于环境空气污染与亚临床脑血管疾病独立相关。
