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Will the real bile acid sulfotransferase please stand up? Identification of as a major hepatic bile acid sulfonating enzyme in mice.

作者信息

Dawson Paul A, Setchell Kenneth D R

机构信息

Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, GA 30322

Department of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.

出版信息

J Lipid Res. 2017 Jun;58(6):1033-1035. doi: 10.1194/jlr.C077420. Epub 2017 Apr 28.

DOI:10.1194/jlr.C077420
PMID:28455387
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5454499/
Abstract
摘要

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1
Identification and characterization of a novel PPARα-regulated and 7α-hydroxyl bile acid-preferring cytosolic sulfotransferase mL-STL (Sult2a8).一种新型的过氧化物酶体增殖物激活受体α（PPARα）调控的、偏好7α-羟基胆汁酸的胞质磺基转移酶mL-STL（Sult2a8）的鉴定与表征
J Lipid Res. 2017 Jun;58(6):1114-1131. doi: 10.1194/jlr.M074302. Epub 2017 Apr 25.
2
Activation of Male Liver Chromatin Accessibility and STAT5-Dependent Gene Transcription by Plasma Growth Hormone Pulses.血浆生长激素脉冲激活雄性肝脏染色质可及性和STAT5依赖性基因转录
Endocrinology. 2017 May 1;158(5):1386-1405. doi: 10.1210/en.2017-00060.
3
Updated perspectives on the cytosolic sulfotransferases (SULTs) and SULT-mediated sulfation.胞质磺基转移酶（SULTs）及SULT介导的硫酸化作用的最新观点
Biosci Biotechnol Biochem. 2017 Jan;81(1):63-72. doi: 10.1080/09168451.2016.1222266. Epub 2016 Sep 21.
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Nod2 deficiency protects mice from cholestatic liver disease by increasing renal excretion of bile acids.Nod2基因缺陷通过增加胆汁酸的肾脏排泄来保护小鼠免受胆汁淤积性肝病的影响。
J Hepatol. 2014 Jun;60(6):1259-67. doi: 10.1016/j.jhep.2014.02.012. Epub 2014 Feb 19.
5
The profile of bile acids and their sulfate metabolites in human urine and serum.胆汁酸及其硫酸代谢物在人尿液和血清中的特征。
J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Dec 30;942-943:53-62. doi: 10.1016/j.jchromb.2013.10.019. Epub 2013 Oct 22.
6
Ostα depletion protects liver from oral bile acid load.Ostα 耗竭可保护肝脏免受口服胆汁酸负荷的影响。
Am J Physiol Gastrointest Liver Physiol. 2011 Sep;301(3):G574-9. doi: 10.1152/ajpgi.00141.2011. Epub 2011 Jun 30.
7
Simultaneous characterization of bile acids and their sulfate metabolites in mouse liver, plasma, bile, and urine using LC-MS/MS.采用 LC-MS/MS 同时检测小鼠肝、血浆、胆汁和尿液中的胆汁酸及其硫酸盐代谢物。
J Pharm Biomed Anal. 2011 Jul 15;55(5):1111-9. doi: 10.1016/j.jpba.2011.03.035. Epub 2011 Apr 6.
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Kinetic analysis of bile acid sulfation by stably expressed human sulfotransferase 2A1 (SULT2A1).通过稳定表达的人磺基转移酶2A1（SULT2A1）对胆汁酸硫酸化的动力学分析。
Xenobiotica. 2010 Mar;40(3):184-94. doi: 10.3109/00498250903514607.
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Bile Acid sulfation: a pathway of bile acid elimination and detoxification.胆汁酸硫酸化：胆汁酸消除与解毒的一条途径。
Toxicol Sci. 2009 Apr;108(2):225-46. doi: 10.1093/toxsci/kfn268. Epub 2009 Jan 8.
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Age- and sex-dependent expression of multiple murine hepatic hydroxysteroid sulfotransferase (SULT2A) genes.多种小鼠肝脏羟基类固醇硫酸转移酶（SULT2A）基因的年龄和性别依赖性表达。
Biochem Pharmacol. 2008 Oct 15;76(8):1036-46. doi: 10.1016/j.bcp.2008.07.032. Epub 2008 Aug 5.