Bertasi Giampietro, Cole Windy, Samsell Brian, Qin Xiaofei, Moore Mark
University of Padua, Padua, Italy.
Robinson Wound Care Center, 1533 South Water Street, Kent, OH, 44240, USA.
Cell Tissue Bank. 2017 Sep;18(3):403-411. doi: 10.1007/s10561-017-9628-3. Epub 2017 Apr 28.
Human acellular dermal matrices (ADMs) are used successfully in a variety of procedures, including sports medicine related, wound repair, and breast reconstructions, but the mechanism of repair is still not fully understood. An opportunity to explore this mechanism presented itself when a patient experienced a rerupture of the native tendon due to a fall that occurred 2 months after undergoing an Achilles tendon repair using Matracell treated ADM. The ADM was removed and an extensive histology analysis was performed on the tissue. Additionally, a literature review was conducted to determine the mechanism of ADM integration into the tendon structure and explore if differences in this mechanism exist for different types of human ADMS. The histology analysis demonstrated that the healing process during a tendon reconstruction procedure is similar to that of wound healing. Furthermore, the literature review showed that differences exist in the mechanism for integration among various human ADMs and that these differences may be due to variances in the methods and technologies that manufactures use to process human ADMs.
人脱细胞真皮基质（ADM）已成功应用于多种手术，包括与运动医学相关的手术、伤口修复和乳房重建，但修复机制仍未完全明确。一名患者在使用Matracell处理的ADM进行跟腱修复2个月后因跌倒导致原肌腱再次断裂，这为探索该机制提供了契机。取出ADM并对组织进行了广泛的组织学分析。此外，还进行了文献综述，以确定ADM整合到肌腱结构中的机制，并探讨不同类型的人ADM在该机制上是否存在差异。组织学分析表明，肌腱重建过程中的愈合过程与伤口愈合相似。此外，文献综述表明，各种人ADM之间的整合机制存在差异，这些差异可能是由于制造商用于处理人ADM的方法和技术不同所致。
