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使用脱细胞真皮基质DermACELL(®)治疗严重烧伤。

Treatment of severe burn with DermACELL(®), an acellular dermal matrix.

作者信息

Chen Shyi-Gen, Tzeng Yuan-Sheng, Wang Chih-Hsin

机构信息

Department of Plastic and Reconstructive Surgery, Tri-Service General Hospital, National Defense Medical Center Taipei, Taiwan.

出版信息

Int J Burns Trauma. 2012;2(2):105-9. Epub 2012 Sep 15.

Abstract

For treatment of skin burn injuries, there exist several methods of treatment related to tissue regeneration, including the use of autograft skin and cryopreserved skin. However, each method has drawbacks. An alternative method for tissue regeneration is allograft acellular dermal matrix, with potential as a biocompatible scaffold for new tissue growth. One recently produced material of this type is DermACELL(®), which was used in this case presentation for treating a scar resulting from second- and third-degree burns in a 33-year-old female patient. The patient presented with significant hypertrophic scarring from the elbow to the hand and with limited wrist and elbow motion. The scarring was removed, and the patient was treated with a 1:3 mesh of DermACELL. The wound was resurfaced with a split thickness skin graft, and postoperative care included application of pressure garment and silicone sheet, as well as range of motion exercise and massage. At 30 days after DermACELL application, the wound appeared well-healed with little scar formation. At 180 days post-application, the wound continued to appear healed well without significant scar formation. Additionally, the wound was supple, and the patient experienced significant improvement in range of motion. In the case presented, DermACELL appears to have been a successful method of treatment for scarring due to severe burns by preventing further scar formation and improving range of motion.

摘要

对于皮肤烧伤的治疗,存在几种与组织再生相关的治疗方法,包括使用自体皮肤和冷冻保存的皮肤。然而,每种方法都有缺点。组织再生的一种替代方法是同种异体脱细胞真皮基质,它有潜力作为新组织生长的生物相容性支架。最近生产的这种类型的一种材料是DermACELL(®),在本病例报告中用于治疗一名33岁女性患者因二度和三度烧伤导致的疤痕。患者肘部至手部出现明显的增生性疤痕,手腕和肘部活动受限。切除疤痕后,患者接受了1:3网状的DermACELL治疗。伤口用中厚皮片覆盖,术后护理包括使用压力衣和硅胶片,以及进行活动范围锻炼和按摩。在应用DermACELL 30天后,伤口愈合良好,几乎没有疤痕形成。在应用后180天,伤口继续愈合良好,没有明显的疤痕形成。此外,伤口柔软,患者的活动范围有显著改善。在本病例中,DermACELL似乎是一种成功的治疗严重烧伤疤痕的方法,它可以防止进一步的疤痕形成并改善活动范围。

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