Rossi F, Quirico N, Carillo C
Istituto di Ricovero e Cura a Carattere Scientifico Sanatrix, Venafro, Isernia.
Riv Neurol. 1988 May-Jun;58(3):127-30.
The effect of chronic ethanol administration (8% in the drinking water for 28 days) on opiate receptor function at striatal level was studied in adult (3 months) and aged (24 months) male Sprague Dawley rats. The treatment produces supersensitivity of striatal delta opiate receptors which may be ascribed to an inhibitory effect of ethanol on endogenous opiate release. In contrast the affinity of mu receptors is decreased. These changes are qualitatively and quantitatively similar in young and old rats.
在成年（3个月）和老年（24个月）雄性斯普拉格-道利大鼠中，研究了长期给予乙醇（饮用水中含8%乙醇，持续28天）对纹状体水平阿片受体功能的影响。该处理导致纹状体δ阿片受体超敏，这可能归因于乙醇对内源性阿片释放的抑制作用。相反，μ受体的亲和力降低。这些变化在年轻和老年大鼠中在性质和数量上相似。
