慢性乙醇会改变大鼠纹状体中的阿片受体功能。

Chronic ethanol changes opiate receptor function in rat striatum.

作者信息

Lucchi L, Rius R A, Uzumaki H, Govoni S, Trabucchi M

出版信息

Brain Res. 1984 Feb 20;293(2):368-71. doi: 10.1016/0006-8993(84)91245-9.

PMID:6320974

Abstract

Ethanol produces supersensitivity of striatal delta-opiate receptor sites labeled by [3H]DADLE and [3H]etorphine. The impairment may be ascribed to the diminished enkephalin release detected in rat striatum after chronic ethanol consumption. On the contrary, a lower affinity of striatal mu-opiate receptors results after same ethanol exposure. In fact, the Kd values of [3H]Met-enkephalin and [3H]DHM are enhanced when measured in striata of ethanol-dependent rats. The diverse sensitivity of the various classes of opiate receptors to ethanol may be ascribed to different ethanol effects on enkephalinergic transmission.

摘要

乙醇会使由[3H]DADLE和[3H]埃托啡标记的纹状体δ-阿片受体位点产生超敏反应。这种损害可能归因于长期摄入乙醇后在大鼠纹状体中检测到的脑啡肽释放减少。相反，相同乙醇暴露后纹状体μ-阿片受体的亲和力降低。事实上，在乙醇依赖大鼠的纹状体中测量时，[3H]甲硫氨酸脑啡肽和[3H]二氢吗啡的Kd值会升高。各类阿片受体对乙醇的不同敏感性可能归因于乙醇对脑啡肽能传递的不同影响。