一氧化氮的免疫生物学与诱导型一氧化氮合酶的调节
Immunobiology of Nitric Oxide and Regulation of Inducible Nitric Oxide Synthase.
作者信息
Lee Martin, Rey Kevin, Besler Katrina, Wang Christine, Choy Jonathan
机构信息
Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada.
出版信息
Results Probl Cell Differ. 2017;62:181-207. doi: 10.1007/978-3-319-54090-0_8.
Nitric oxide (NO) is a bioactive gas that has multiple roles in innate and adaptive immune responses. In macrophages, nitric oxide is produced by inducible nitric oxide synthase upon microbial and cytokine stimulation. It is needed for host defense against pathogens and for immune regulation. This review will summarize the role of NO and iNOS in inflammatory and immune responses and will discuss the regulatory mechanisms that control inducible nitric oxide synthase expression and activity.
一氧化氮（NO）是一种生物活性气体，在先天性和适应性免疫反应中具有多种作用。在巨噬细胞中，一氧化氮是由诱导型一氧化氮合酶在微生物和细胞因子刺激下产生的。它对于宿主抵御病原体和免疫调节是必需的。本综述将总结一氧化氮和诱导型一氧化氮合酶在炎症和免疫反应中的作用，并将讨论控制诱导型一氧化氮合酶表达和活性的调节机制。
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