N 端促肾上腺皮质激素片段可增加阿尔茨海默型痴呆患者脑脊液中β-内啡肽的含量。

N-terminal ACTH fragments increase the CSF beta-EP content in Alzheimer type dementia.

作者信息

Nappi G, Facchinetti F, Martignoni E, Petraglia F, Sinforiani E, Bono G, Genazzani A R

机构信息

Department of Neurology, C. Mondino Foundation, University of Pavia, Italy.

出版信息

Acta Neurol Scand. 1988 Aug;78(2):146-51. doi: 10.1111/j.1600-0404.1988.tb03636.x.

DOI:10.1111/j.1600-0404.1988.tb03636.x

PMID:2845700

Abstract

Eleven patients with presenile Alzheimer type dementia (ATD) were treated with N-terminal ACTH fragments for 14 days. No change in cognitive functions was observed during the treatment. A significant increase in CSF beta-endorphin (beta-EP) levels was found, while ACTH and beta-lipoprotein remain unaffected. The possibility that ACTH and its moieties could interfere with beta-EP activities in CNS is discussed.

摘要

11例早老型阿尔茨海默病（ATD）患者接受N端促肾上腺皮质激素（ACTH）片段治疗14天。治疗期间未观察到认知功能变化。发现脑脊液β-内啡肽（β-EP）水平显著升高，而促肾上腺皮质激素和β-脂蛋白未受影响。讨论了促肾上腺皮质激素及其部分可能干扰中枢神经系统中β-EP活性的可能性。